- Clone
- SHM16 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Ephrin type-A receptor 2 (EPHA2), Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, Myk2, Sek2, EPH receptor A2, eEpithelial cell receptor protein tyrosine kinase, Protein tyrosine kinase, Soluble EPHA2 variant 1
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
356801 | 25 µg | £77 | ||||
356802 | 100 µg | £182 |
Ephrin receptor A2 (EphA2), also known as Eck, is a 130 kD type I transmembrane glycoprotein which belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EphA2 is expressed on epithelial cells, keratinocytes, dendritic/Langerhans cells and melanocytes. It has also been observed in breast, cervical, ovarian, prostate, colon, skin and lung cancers. EphA2 is an oncoprotein which is an essential survival factor for many melanomas. EphA2 plays an important role in angiogenesis and tumor neovascularization through interaction with ephrin-A1, -A3, -A4 and -A5.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
-
AB_2561804 (BioLegend Cat. No. 356801)
AB_2561804 (BioLegend Cat. No. 356802)
Antigen Details
- Structure
- Type I transmembrane glycoprotein, 130 kD, protein- tyrosine kinase family
- Distribution
- Epithelium (keratinocytes, renal collecting duct cells, carcinomas), dendritic/Langerhans cells, melanocytes
- Function
- Angiogenesis and tumor neovascularization
- Ligand/Receptor
- Ephrin-A1, -A3, -A4, -A5
- Cell Type
- Epithelial cells, Langerhans cells, Dendritic cells
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Biology, Immunology, Neuroscience, Synaptic Biology
- Molecular Family
- Adhesion Molecules, Protein Kinases/Phosphatase
- Antigen References
-
1. Pandey A, et al. 1994. J. Biol. Chem. 269:30154.
2. Sulman E, et al. 1997. Genomics 40:371.
3. Pratt R, et al. 2002. Oncogene 21:7690.
4. Udayakumar D, et al. 2011. Oncogene 30:4921.
5. Brantley-Sieders D, et al. 2008. J. Clin. Invest. 118:64. - Gene ID
- 1969 View all products for this Gene ID
- UniProt
- View information about EphA2 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All EphA2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human EphA2 | SHM16 | FC |
PE anti-human EphA2 | SHM16 | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-human EphA2
Human melanoma cell line, A375, was stained with purified Ep... -
PE anti-human EphA2
Human melanoma cell line, A375, was stained with EphA2 (clon...
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