Purified anti-human EPHB6 Antibody

Pricing & Availability
Clone
T49-25 (See other available formats)
Regulatory Status
RUO
Other Names
Ephrin Type-B Receptor 6, Eph receptor B6, tyrosine-protein kinase-defective receptor B6
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
T49-25_PURE_EPHB6_Antibody_100722
Human peripheral blood lymphocytes were stained with anti-human CD3 FITC and purified anti-human EPHB6 (clone T49-25) (left) or purified mouse IgG1, κ isotype control (right) followed by PE anti-mouse IgG.
  • T49-25_PURE_EPHB6_Antibody_100722
    Human peripheral blood lymphocytes were stained with anti-human CD3 FITC and purified anti-human EPHB6 (clone T49-25) (left) or purified mouse IgG1, κ isotype control (right) followed by PE anti-mouse IgG.
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384302 100 µg £260
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Description

EPHB6 is a 110 kD protein transmembrane protein of the ephrin receptor family of tyrosine kinases, but lacks kinase activity. It is expressed on skin keratinocytes, neurons, thymocytes, immature T Cells, and a small population of peripheral CD4+ T Cells and CD8+ T Cells. Loss of EPHB6 expression has been related with increased metastatic melanoma and neuroblastoma, suggesting a role in suppressing tumorigenicity.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
GST-fusion extracellular domain region 3 of human EPHB6 recombinant protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2927928 (BioLegend Cat. No. 384302)

Antigen Details

Structure
110 kD transmembrane protein, tyrosine kinase
Distribution

T lymphocytes, thymocytes, neurons, keratinocytes

Ligand/Receptor
Ephrin B6, Ephrin B2, Ephrin B1
Cell Type
Neurons, T cells
Biology Area
Cancer Biomarkers, Cell Biology, Immunology, Neuroscience
Antigen References
  1. Matsuoka H, et al. 2005. J Biol Chem. 280:29355-63
  2. Strozen T, et al. 2021. Int J Mol Sci. 22:821
  3. Zhou R. 1998. Pharm Ther. 77:151-81
Gene ID
2051 View all products for this Gene ID
UniProt
View information about EPHB6 on UniProt.org
Go To Top Version: 1    Revision Date: 10/07/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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