Purified anti-human FPR1 Antibody anti-FPR1

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Clone: W15086B (See other available formats)
Regulatory Status: RUO
Other Names: fMet-Leu-Phe receptor 1, FMLP, FPR, fMLF-R
Isotype: Mouse IgG1, κ
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W15086B_PURE_FPR1_Antibody_040717 — Human peripheral blood leukocytes were stained with purified anti-human FPR1 (Clone W15086B) (filled histogram) or purified mouse IgG1 κ isotype control (open histogram), followed by goat anti-mouse IgG PE. Data shown was gated on granulocyte population.

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391602

100 µg

£157

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Description

FPR1 (Formyl Peptide Receptor 1), a G protein-coupled receptor consisting of seven transmembrane domains, is expressed on phagocytic cells and other cell types such as monocytes. FPR1 is a high affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. Endogenous peptide ligands for this receptor have also been identified. FPR1 mediates the response to invasion of the host by microbial pathogens and is important in host defense and inflammation.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Full length human FPR1 transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2687020 (BioLegend Cat. No. 391602)

Antigen Details

Structure: Seven transmembrane domains, G-protein coupled receptor (GPCR)
Distribution: Monocytes, Neutrophils
Function: Chemotaxis
Ligand/Receptor: N-formylated peptides, Ac9-25, FAM19A4, Annexin A1
Cell Type: Monocytes, Neutrophils, Eosinophils
Biology Area: Immunology, Innate Immunity
Antigen References: 1. Boulay F, et al. 1990. Biochemistry 29:11123.
2. Ye RD, et al. 2009. Pharmacol. Rev. 61:119.
3. Prossnitz ER, et al. 1999. Biochemistry 38:2240.
4. Wang W, et al. 2015. Cell Mol. Immunol. 12:615.
Gene ID: 2357 View all products for this Gene ID
UniProt: View information about FPR1 on UniProt.org

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Other Formats

View All FPR1 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human FPR1	W15086B	FC
FITC anti-human FPR1	W15086B	FC
PerCP/Cyanine5.5 anti-human FPR1	W15086B	FC
PE anti-human FPR1	W15086B	FC
APC anti-human FPR1	W15086B	FC

Certificate of Analysis

Go To Top Version: 0 Revision Date: 04/10/2017

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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