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Purified anti-human FPR1 Antibody

Pricing & Availability
Clone
W15086B (See other available formats)
Regulatory Status
RUO
Other Names
fMet-Leu-Phe receptor 1, FMLP, FPR, fMLF-R
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
W15086B_PURE_FPR1_Antibody_040717
Human peripheral blood leukocytes were stained with purified anti-human FPR1 (Clone W15086B) (filled histogram) or purified mouse IgG1 κ isotype control (open histogram), followed by goat anti-mouse IgG PE. Data shown was gated on granulocyte population.
  • W15086B_PURE_FPR1_Antibody_040717
    Human peripheral blood leukocytes were stained with purified anti-human FPR1 (Clone W15086B) (filled histogram) or purified mouse IgG1 κ isotype control (open histogram), followed by goat anti-mouse IgG PE. Data shown was gated on granulocyte population.
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391602 100 µg £157
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Description

FPR1 (Formyl Peptide Receptor 1), a G protein-coupled receptor consisting of seven transmembrane domains, is expressed on phagocytic cells and other cell types such as monocytes.  FPR1 is a high affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors.  Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release.  Endogenous peptide ligands for this receptor have also been identified.   FPR1 mediates the response to invasion of the host by microbial pathogens and is important in host defense and inflammation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Full length human FPR1 transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Zhang M, et al. 2023. Nat Commun. 7847:14. PubMed
RRID
AB_2687020 (BioLegend Cat. No. 391602)

Antigen Details

Structure
Seven transmembrane domains, G-protein coupled receptor (GPCR)
Distribution

Monocytes, Neutrophils

Function
Chemotaxis
Ligand/Receptor
N-formylated peptides, Ac9-25, FAM19A4, Annexin A1
Cell Type
Monocytes, Neutrophils, Eosinophils
Biology Area
Immunology, Innate Immunity
Antigen References

1. Boulay F, et al. 1990. Biochemistry 29:11123.
2. Ye RD, et al. 2009. Pharmacol. Rev. 61:119.
3. Prossnitz ER, et al. 1999. Biochemistry 38:2240.
4. Wang W, et al. 2015. Cell Mol. Immunol. 12:615.

Gene ID
2357 View all products for this Gene ID
UniProt
View information about FPR1 on UniProt.org
Go To Top Version: 0    Revision Date: 04/10/2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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