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- Clone
- MaP.DM1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- HLADM
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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Human peripheral blood lymphocytes were fixed, permeabilized, and then stained with purified HLA-DM (clone MaP.DM1, filled histogram) or mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG FITC.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 358002 | 100 µg | £130 | ||||
HLA-DM is a non-classical MHC molecule, comprised of one α chain and one β chain, which is expressed by antigen presenting cells. HLA-DM acts as a chaperon that stabilizes the MHC class II molecule in the lyzosome, while enhances the exchange of CLIP for the antigenic peptide.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- MHC class II enriched organelles from the B cell line Pala.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
ICFC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
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Application References
(PubMed link indicates BioLegend citation) -
- Hammond C, et al. 1998. J. Immunol. 161:3282.
- Faubert A, et al. 2002. J. Biol. Chem. 277:2750.
- Xiu F, et al. 2011. J. Immunol. 187:1547.
- Product Citations
-
- RRID
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AB_2562026 (BioLegend Cat. No. 358002)
Antigen Details
- Structure
- Heterodimer comprising one α and one β chain.
- Distribution
- Antigen presenting cells.
- Function
- Facilitates the exchange of CLIP for the antigenic peptide in the grove of the MHC class II molecule, maintaining the tertiary structure of this molecule during the process.
- Interaction
- MHC class II
- Cell Type
- Antigen-presenting cells, B cells, Dendritic cells
- Biology Area
- Immunology
- Molecular Family
- MHC Antigens
- Gene ID
- 3108 View all products for this Gene ID 3109 View all products for this Gene ID
- UniProt
- View information about HLA-DM on UniProt.org
Related FAQs
Other Formats
View All HLA-DM Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human HLA-DM | MaP.DM1 | ICFC |
| PE anti-human HLA-DM | MaP.DM1 | ICFC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human HLA-DM
Human peripheral blood lymphocytes were fixed, permeabilized... -
PE anti-human HLA-DM
Human peripheral blood lymphocytes were surface stained with... 
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