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Purified anti-human IL-1RL1 (ST2) Antibody

Pricing & Availability
Clone
A16008J (See other available formats)
Regulatory Status
RUO
Other Names
IL-33R, ST2, IL-1RL1
Isotype
Mouse IgG2b, κ
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Product Citations
publications
A16008J_PURE_IL-1RL1_Antibody_030422
Human peripheral blood mononuclear cells were stimulated with IL-3 overnight and stained with anti-human HLA-DR APC, anti-human CD123 PE/Dazzle 594™ and purified anti-human IL-1RL1 (ST2) (clone A16008J) (left) or mouse IgG2b, κ isotype control (right) followed by PE anti-mouse IgG. Data shown was gated on HLA-DR negative cells.
  • A16008J_PURE_IL-1RL1_Antibody_030422
    Human peripheral blood mononuclear cells were stimulated with IL-3 overnight and stained with anti-human HLA-DR APC, anti-human CD123 PE/Dazzle 594™ and purified anti-human IL-1RL1 (ST2) (clone A16008J) (left) or mouse IgG2b, κ isotype control (right) followed by PE anti-mouse IgG. Data shown was gated on HLA-DR negative cells.
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379402 100 µg £289
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Description

IL1RL1 is a member of the Toll-like receptor superfamily the receptor for Interleukin-33. It is a 556 amino acid single-pass type I membrane protein. ST2 exists in two forms as splice variants: a soluble form, which acts as a decoy receptor and sequesters free IL-33, and a membrane-bound form (ST2), which activates the MyD88/NF-κB signaling pathway. Signaling through IL1RL1 drives cytokine production in mast cells, basophils, eosinophils, invariant NKT and NK cells, Th2 lymphocytes, and type 2 innate immune cells. IL-33 signaling is required for maintaining the suppressive function of regulatory T cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human IL-1RL1, AA19-328
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2910446 (BioLegend Cat. No. 379402)

Antigen Details

Structure
Single-pass type I membrane protein
Distribution

Th2 lymphocytes, mast cells, eosinophils, basophils, smooth muscle cells, endothelial cells

Function
Cytokine signaling
Interaction
Signaling requires association of the coreceptor IL1RAP. Recruits MYD88, IRAK1, IRAK4, and TRAF6.
Ligand/Receptor
IL-33
Cell Type
Basophils, Endothelial cells, Eosinophils, Lymphocytes, NK cells, Th2, Tregs
Biology Area
Immunology
Molecular Family
Cytokine/Chemokine Receptors
Antigen References
  1. Schmitz J, et al. 2005. Immunity. 23: 479-490.
  2. Brint E, et al. 2004. Nat Immun. 5:373-379.
  3. Griesenauer B, et al. 2017. Front Immunol. 8:475.
Gene ID
9173 View all products for this Gene ID
UniProt
View information about IL-1RL1 on UniProt.org
Go To Top Version: 1    Revision Date: 03/04/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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