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Purified anti-human LAMP5 Antibody

Pricing & Availability
Clone
124-40B (See other available formats)
Regulatory Status
RUO
Other Names
UNC-43, BADLAMP, BAD-LAMP, C20orf103
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
124-40B_Purified_LAMP5_Antibody_FC_1_120712
Human peripheral blood mononuclear cells were surface stained with CD303 APC, fixed and permeabilized with BioLegend's FOXP3 Fix/Perm Buffer Set (Cat# 421403), and then stained with purified LAMP5 (clone 124-40B) (top) or mouse IgG1, κ isotype control (bottom), followed by anti-mouse IgG1 PE.
  • 124-40B_Purified_LAMP5_Antibody_FC_1_120712
    Human peripheral blood mononuclear cells were surface stained with CD303 APC, fixed and permeabilized with BioLegend's FOXP3 Fix/Perm Buffer Set (Cat# 421403), and then stained with purified LAMP5 (clone 124-40B) (top) or mouse IgG1, κ isotype control (bottom), followed by anti-mouse IgG1 PE.
  • 124-40B_Purified_LAMP5_Antibody_FC_2_120712
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355802 100 µg £230
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Description

Lysosome-associated membrane protein 5 (LAMP5), also known as BAD-LAMP, UNC-43, and C20orf103, is a new member of LAMP family.  It is a transmembrane glycosylated protein localized in the ER-Golgi intermediate compartment (ERGIC). LAMP5 shares sequence and structural homology with the canonical LAMP1 (CD107a) and LAMP2 (CD107b) molecules, harbors an endosomal addressing signal within its cytoplasmic tail, and contains several conserved cysteine residues that allow for the formation of particular structural loops known as LAMP folds. In mice, LAMP5 is expressed in postnatal cortical neurons of particular layers, where it is enriched in defined zones along neuronal projections. Human LAMP5, like its murine homolog, is principally expressed in brain; it is also specifically found in primary CD303 (BDCA-2)-positive pDCs (plasmacytoid dendritic cells).  It represents a novel marker of human primary and transformed pDCs.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Cells expressing C20orf103.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining using our nuclear factor staining protocol. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Additional Product Notes

View more applications data using a previous version of this product in our Scientific Poster Library.

RRID
AB_2561712 (BioLegend Cat. No. 355802)

Antigen Details

Structure
A transmembrane glycosylated protein
Distribution

pDCs

Cell Type
Dendritic cells
Biology Area
Immunology
Antigen References

1. Defays A, et al. 2011. Blood 118:609.
2. David A, et al. 2007. J. Cell. Sci. 120:353.

Gene ID
24141 View all products for this Gene ID
UniProt
View information about LAMP5 on UniProt.org
Go To Top Version: 1    Revision Date: 12/10/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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