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Purified anti-human PTX3 Antibody

Pricing & Availability
Clone
MNB5 (See other available formats)
Regulatory Status
RUO
Other Names
PTX-3, Pentraxin 3, TSG-14, TNFAIPS, Tumor Necrosis Factor Inducible Gene 14 Protein, Tumor Necrosis Factor Alpha-Induce Protein 5, TNF Alpha-Induced Protein 5
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
RECOM_HU_PTX3_080119.png
Figure was created using pure MNB5 (Cat. NO 537902) antibody as the capture in a sandwich ELISA assay in conjunction with the biotinylated MNB4 antibody (Cat. No. 538004) as the detection antibody and recombinant Human PTX3 (ELISA Std.) (Cat. No. 786109).
  • RECOM_HU_PTX3_080119.png
    Figure was created using pure MNB5 (Cat. NO 537902) antibody as the capture in a sandwich ELISA assay in conjunction with the biotinylated MNB4 antibody (Cat. No. 538004) as the detection antibody and recombinant Human PTX3 (ELISA Std.) (Cat. No. 786109).
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537902 500 µg £398
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Description

PTX3 is part of the pentraxin family which is characterized by a cyclic multimeric structure. Penatraxins are acute phase proteins that act as pattern recognition receptors. PTX3 is a long pentraxin containing a C terminal domain similar to other members of the pentraxin family and a unique N terminal domain. Inflammatory signals stimulate PTX3 production by a variety of cells including mononuclear phagocytes, dendritic cells, fibroblasts, and endothelial cells.

Serum levels of PTX3 increase rapidly in response to a variety of inflammatory and infectious conditions including endotoxic shock and sepsis. PTX3 has been proposed as an early diagnostic marker for septic shock. PTX3 can activate the classical complement pathway, aiding in pathogen recognition by macrophages and dendritic cells. PTX3 is also believed to play an important role in protection against autoimmunity by enhancing complement-mediated clearing of apoptotic cells and restricting cross presentation. Current research has also indicated that PTX3 is involved in initiating the process of tissue repair and plays a role in female fertility. PTX3 is believed to be involved in cancer-related inflammation and high PTX3 levels have been correlated with clinical stage and severity for various cancers.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant Human PTX3
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ELISA Capture - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by ELISA assay. For ELISA Capture applications, a concentration range of 2.0 - 8.0 µg/mL is recommended. To obtain a linear standard curve, serial dilutions of PTX3 recombinant protein ranging from 6000 to 93.75 pg/mL is recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The pure MNB5 (Cat. No. 537902) antibody is useful as the capture antibody in a sandwich ELISA assay, when used in conjunction with the biotinylated MNB4 antibody (Cat. No. 538004) as the detection antibody and Recombinant Human PTX3 (ELISA Std.) (Cat. No. 786109).

RRID
AB_2814447 (BioLegend Cat. No. 537902)

Antigen Details

Structure
Homooctamer
Distribution

Dendritic cells, Endothelial cells, Fibroblasts, Monocytes

Function
Plays roles in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components, and female fertility.
Cell Type
Dendritic cells, Endothelial cells, Fibroblasts, Monocytes
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Innate Immunity
Gene ID
5806 View all products for this Gene ID
UniProt
View information about PTX3 on UniProt.org
Go To Top Version: 1    Revision Date: 08/01/2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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