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Purified anti-human TMPRSS11E (DESC1) Antibody

Pricing & Availability
Clone
TM191 (See other available formats)
Regulatory Status
RUO
Other Names
Transmembrane protease serine 11E, TMPRSS11E2, differentially expressed in squamous cell carcinoma 1, DESC1
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
TM19_PURE_TMPRSS11E_1_082517
TMPRSS11E transfected BAF3 cells were stained with purified anti-TMPRSS11E (Clone TM191, filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE
  • TM19_PURE_TMPRSS11E_1_082517
    TMPRSS11E transfected BAF3 cells were stained with purified anti-TMPRSS11E (Clone TM191, filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE
  • TM19_PURE_TMPRSS11E_2_082517
    Metastatic colorectal adenocarcinoma Colo205 cells were stained with purified anti-TMPRSS11E (Clone TM191, filled histogram) or purified mouse IgG1,κ isotype control (open histogram), followed by anti-mouse IgG PE.
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392002 100 µg £182
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Description

TMPRSS11E also called DESC1 is a type II transmembrane serine protease. It is a tumor suppressor to sensitize cell apoptosis through downregulation of the EGFR/AKT pathway.  Expression of TMPRSS11E may be involved in up/down regulation for a particular protease among different types of cancers. TMPRSS11E gene expression is shown to be reduced or absent in squamous cell carcinoma, while overexpression of the gene has been seen in kidney, brain and breast cancer carcinomas. It has been reported that cells forced to express TMPRSS11E have an increased ability of cellular infiltration.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Purified recombinant TMPRSS11E.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Niemeyer BF, et al. 2021. Nano Sel. . PubMed
RRID
AB_2715790 (BioLegend Cat. No. 392002)

Antigen Details

Distribution

Epithelial cells. Tissue-specific expression occurs from the head and neck, skin, prostate and testes.

Function
Serine protease which has gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.
Interaction
Extracellular region (Ser159-IIE423).
Cell Type
Epithelial cells
Biology Area
Cancer Biomarkers, Cell Biology
Antigen References

1.Lang JC, et al. 2001. Br J Cancer. 84(2):237
2. Ng HY, et al. 2016. Int J Cancer. 138(12):294
3. Viloria C G, et al. 2007. Br J Cancer. 97(2): 201
4. Sedghizadeh PP. et al. 2006. Head Neck. 28(5):432
5. Behrens M. et al. 2004. 61(22):2866

Gene ID
28983 View all products for this Gene ID
UniProt
View information about TMPRSS11E on UniProt.org
Go To Top Version: 0    Revision Date: 08/28/2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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