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Purified anti-human TSPAN33 (BAAM) Antibody

Pricing & Availability
Clone
SA17RN1 (See other available formats)
Regulatory Status
RUO
Other Names
Tetraspanin-33, BAAM, Penumbra, PEN
Isotype
Mouse IgG2b, κ
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Product Citations
publications
/SA17RN1_Purified_TSPAN33_Antibody_122718.png
Human peripheral blood lymphocytes resting (right) or stimulated overnight with recombinant human CD40L (TNFSF5) plus IL-4 (left), were stained with purified TSPAN33 (clone SA17RN1) followed by anti-mouse IgG PE and CD19 APC.
  • /SA17RN1_Purified_TSPAN33_Antibody_122718.png
    Human peripheral blood lymphocytes resting (right) or stimulated overnight with recombinant human CD40L (TNFSF5) plus IL-4 (left), were stained with purified TSPAN33 (clone SA17RN1) followed by anti-mouse IgG PE and CD19 APC.
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395402 100 µg £201
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Description

TSPAN33, also known as BAAM, is a 32 kDa protein member of the TM4 superfamily (TM4SF). TSPAN33 have four transmembrane regions and two extracellular loops, one of them is a cysteine-rich long extracellular loop (LEL), characteristic of the TM4SF. TSPAN33 interacts with different molecules such as integrins and other tetraspanins. TSPAN33 is expressed by activated B cells, some B cell lymphomas, macrophages and in cells from the convoluted tubules and collecting ducts in the kidney. In macrophages TSPAN33 modulates TLR-induced proinflammatory gene expression, but its function in other cells is unknown.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human TSPAN33-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Navarro-Hernandez IC, et al. 2020. FEBS J. 287:3449. PubMed
RRID
AB_2783314 (BioLegend Cat. No. 395402)

Antigen Details

Structure
Member of the TM4 superfamily, TspanC8 subgroup, 32kD, 4 transmembrane regions, 1 cysteine-rich long extracellular loop (LEL).
Distribution

Activated B cells, some B cell lymphomas, macrophages, convoluted tubules and collecting ducts from kidney

Function
Modulates TLR-induced proinflammatory gene expression
Cell Type
B cells, Macrophages
Biology Area
Cancer Biomarkers, Immuno-Oncology, Signal Transduction
Molecular Family
Adhesion Molecules
Antigen References
  1. Pérez-Martínez CA, et al. 2017. Scand J Immunol. 86:23.
  2. Ruiz-García A, et al. 2016. J Immunol. 197:3371.
  3. Luu VP, et al. 2013. Clin Immunol. 149:388.
  4. Chen Z, et al. 2005. Cancer Genet Cytogenet. 162:95.
  5. Maecker HT et al. 1997. FASEB J. 11:428.
Gene ID
340348 View all products for this Gene ID
UniProt
View information about TSPAN33 on UniProt.org
Go To Top Version: 1    Revision Date: 12/27/2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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