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Purified anti-mGluR1 Antibody

Pricing & Availability
Clone
N75/3 (See other available formats)
Regulatory Status
RUO
Other Names
GRM1, mGluR1, GRM1/5
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
N75-3_Purified_mGluR1_Antibody_040519.png
Western blot of Purified anti-mGluR1 antibody (clone N75/3). Lane 1, 5: Molecular weight marker; Lane 2, 6: 40µg of human brain lysate; Lane 3, 7: 20µg of mouse brain lysate; Lane 4, 8: 20 µg of rat brain lysate. The blots were incubated with 5 µg/mL of the primary antibody or mouse IgG1 isotype control overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • N75-3_Purified_mGluR1_Antibody_040519.png
    Western blot of Purified anti-mGluR1 antibody (clone N75/3). Lane 1, 5: Molecular weight marker; Lane 2, 6: 40µg of human brain lysate; Lane 3, 7: 20µg of mouse brain lysate; Lane 4, 8: 20 µg of rat brain lysate. The blots were incubated with 5 µg/mL of the primary antibody or mouse IgG1 isotype control overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
Cat # Size Price Quantity Check Availability Save
861701 25 µg £57
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861702 100 µg £113
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Description

Glutamate Metabotropic Receptor 1, also known as GRM1, is a G protein-coupled receptor that belongs to the group 1 metabotropic glutamate receptor family (mGluR1). GRM1 is an excitatory neurotransmitter receptor involved in hippocampal long-term potentiation and cerebellar long-term depression as demonstrated in an in vivo mouse knockout model of GRM1.These animals also display impaired motor function despite normal brain structure and anatomy compared to their wild type littermates.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Mouse, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This clone detects both monomer and dimer of GRM1.

RRID
AB_2801231 (BioLegend Cat. No. 861701)
AB_2801231 (BioLegend Cat. No. 861702)

Antigen Details

Structure
GRM1 is a 1194 amino acid protein with an apparent molecular mass of ~ 133 kD.
Distribution

Tissue Distribution: Brain
Cellular Distribution: Plasma membrane

Function
GRM1 is a glutamate receptor that regulates synaptic plasticity.
Interaction
Homodimer, HOMER1, HOMER2, HOMER3, SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3, GRASP
Ligand/Receptor
Glutamate
Cell Type
Neurons
Biology Area
Neurodegeneration, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
Molecular Family
Neurotransmitter Receptors, Postsynaptic proteins
Antigen References
  1. Foster DJ and Conn PJ. 2017. Neuron. 94:431
  2. Dravolina OA, et al. 2017. Psychopharmacology (Berl). 234(9-10):1333
  3. Bray N. 2016. Nat Rev Neurosci. 17(10):603
Gene ID
2911 View all products for this Gene ID 14816 View all products for this Gene ID 24414 View all products for this Gene ID
UniProt
View information about mGluR1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 10/29/2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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