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- Clone
- DIH37 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- IL-5Rα, IL-5 Receptor α subunity
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 153402 | 500 µg | £245 | ||||
CD125 is a 60 kD type I transmembrane protein. It is the ligand-specific α subunit of the heterodimeric interleukin 5 (IL-5) receptor. The signal-transducing β subunit of this receptor does not bind to any cytokines and is shared by the receptors for IL-3 and CSF2/GM-CSF. IL-5 is mainly produced by Th2 cells and elevated IL-5 levels are associated with allergic disorders. CD125 has also been found to interact with syndecan binding protein (SDCBP or syntenin), leading to the activation of the transcription factor SOX4. The mouse CD125 is expressed on eosinophils, basophils, and B cells.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Murine IL-5Ralpha-hFcgamma1 fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
-
AB_2715827 (BioLegend Cat. No. 153402)
Antigen Details
- Structure
- 60 kD type I transmembrane protein
- Distribution
-
Eosinophils, basophils and B cells
- Function
- IL-5 receptor
- Interaction
- JAK2, CD131 (IL3RB, CSF2RB), SDCBP
- Ligand/Receptor
- IL-5
- Cell Type
- B cells, Basophils, Eosinophils
- Biology Area
- Cell Biology, Cell Proliferation and Viability, Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Takaki S, et al. 1990. EMBO J. 9:4367
2. Takatsu K, et al. 2011. Proc. Jpn. Acad. Ser B. 87:463.
3. Hitoshi Y, et al. 1990. J. Immunol. 144:4218. - Gene ID
- 16192 View all products for this Gene ID
- UniProt
- View information about CD125 on UniProt.org
Related FAQs
Other Formats
View All CD125 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse CD125 (IL-5Rα) | DIH37 | FC |
| PE anti-mouse CD125 (IL-5Rα) | DIH37 | FC |
| APC anti-mouse CD125 (IL-5Rα) | DIH37 | FC |
| PE/Cyanine7 anti-mouse CD125 (IL-5Rα) | DIH37 | FC |
| TotalSeq™-A1275 anti-mouse CD125 (IL-5Rα) | DIH37 | PG |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-mouse CD125 (IL-5Rα)
Mouse peripheral blood cells were stained with purified CD12... 
-
PE anti-mouse CD125 (IL-5Rα)
Mouse peripheral blood granulocytes were stained with CD193 ... -
APC anti-mouse CD125 (IL-5Rα)
Mouse peripheral blood granulocytes were stained with CD193 ... -
PE/Cyanine7 anti-mouse CD125 (IL-5Rα)
Mouse peripheral blood granulocytes were stained with CD193 ... -
TotalSeq™-A1275 anti-mouse CD125 (IL-5Rα)
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