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Purified anti-mouse CD191 (CCR1) Antibody

Pricing & Availability
Clone
S15040E (See other available formats)
Regulatory Status
RUO
Other Names
CKR1, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1
Isotype
Rat IgG2b, κ
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Product Citations
publications
S15040E_PURE_CCR1_Antibody_FC_092616
Thioglycollate-elicited Balb/C mouse peritoneal macrophages were stained with purified CD191 (clone S15040E, filled histogram) or rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG PE.
  • S15040E_PURE_CCR1_Antibody_FC_092616
    Thioglycollate-elicited Balb/C mouse peritoneal macrophages were stained with purified CD191 (clone S15040E, filled histogram) or rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG PE.
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152502 500 µg £282
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Description

CD191, also known as CCR1, is a seven transmembrane G protein coupled receptor. It is involved in protecting the host from inflammatory responses and viral/parasite invasion, ligands include macrophage inflammatory protein 1 alpha (MIP-1 alpha, ), regulated on activation normal T expressed and secreted protein (RANTES, CCL5), monocyte chemoattractant protein 3 (MCP-3, CCL7), and myeloid progenitor inhibitory factor-1 (MPIF-1, CCL23).

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CCR1-transfectants.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Janela B, et al. 2019. Immunity. 50:1069. PubMed
RRID
AB_2629727 (BioLegend Cat. No. 152502)

Antigen Details

Structure
41KD, seven transmembrane protein.
Distribution

Macrophages, monocytes, neutrophils and eosinophils.

Function
Regulating migration of cells in response to CCL3, CCL5, CCL7 and CCL23.
Ligand/Receptor
CCL3, CCL5, CCL7 and CCL23.
Cell Type
Eosinophils, Macrophages, Monocytes, Neutrophils
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Lionakis MS, et al. 2012. PLoS Pathog. 8:e1002865.
2. Gilliland CT, et al. 2013. J. Biol. Chem. 288:32194.
3. Gong X, et al. 1997. J. Biol. Chem. 272:11682.
4. Daugherty BL, Springer MS. 1997. Genomics. 41:294.
5. Pakianathan DR, et al. 1997. Biochemistry 36:9642.

Gene ID
12768 View all products for this Gene ID
UniProt
View information about CD191 on UniProt.org
Go To Top Version: 1    Revision Date: 09/26/2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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