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Purified anti-mouse CD209B Antibody

Pricing & Availability
Clone
2C7B27 (See other available formats)
Regulatory Status
RUO
Other Names
CD209 antigen-like protein B, DC-SIGN-related protein 1 (DC-SIGNR1)
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
2C7B27_Purified_CD209B_WB_051514
Total lysate from mouse bone marrow cells was resolved by electrophoresis, transferred to nitrocellulose, and probed with purified monoclonal anti- CD209B (clone 2C7B27) antibody. Proteins were visualized using an anti-rat-IgG secondary conjugated to HRP and chemiluminescence detection.
  • 2C7B27_Purified_CD209B_WB_051514
    Total lysate from mouse bone marrow cells was resolved by electrophoresis, transferred to nitrocellulose, and probed with purified monoclonal anti- CD209B (clone 2C7B27) antibody. Proteins were visualized using an anti-rat-IgG secondary conjugated to HRP and chemiluminescence detection.
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147801 25 µg £37
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Description

CD209B, also known as SIGN-R1, is a mouse C-type lectin receptor predominantly expressed on macrophages in the spleen marginal zone and lymph nodes medulla. CD209B is a mouse homolog of human CD209/DC-SIGN and is involved in innate immune response. CD209B mediates the recognition and uptake of pathogen products, such as lipopolysaccharides (LPS), pneumococcal polysaccharides, and dextrans. CD209B has been demonstrated to facilitate the clearance of encapsulated pneumococcus by directly binding to C1q and activating complement through an immunoglobulin independent pathway.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Partial mouse CD209B recombinant protein (74-325 aa)
Formulation
This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
Affinity purified.
Concentration
0.5 mg/ml
Storage & Handling
Upon receipt, store undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2563445 (BioLegend Cat. No. 147801)

Antigen Details

Structure
325 amino acids, predicted molecular weight of 37 kD; single-pass type II membrane protein containing a C-type lectin domain.
Function
CD209B is a C-type lectin receptor, mediating the recognition of various bacteria and viruses during innate immue response.
Ligand/Receptor
CD209B binds to microbial polysaccharides and is a receptor for ICAM-3.
Molecular Family
CD Molecules
Antigen References

1. Zhou Y, et al. 2010. Nat. Med. 16:1128.
2. Saunders SP, et al. 2010. J. Immunol. 184:2627.
3. Silva-Martin N, et al. 2009. Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 65:1264.
4. Saunders SP, et al. 2009. Infect. Immun. 77:399.
5. Park JY, et al. 2009. Neurosci. Lett. 450:246.
6. Lanoue A, et al. J. Exp. Med. 200:1383.

Gene ID
69165 View all products for this Gene ID
UniProt
View information about CD209B on UniProt.org

Related FAQs

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Go To Top Version: 2    Revision Date: 11/20/2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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