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- Clone
- A19079J (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TNFSF12, TNF-related weak inducer of apoptosis
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Mouse TWEAK transfected cells were stained with purified anti-mouse CD255 (TWEAK) (clone A19079J) (filled histogram) or purified mouse IgG2b, κ isotype control (open histogram) followed by PE goat anti-mouse IgG.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 119102 | 100 µg | £238 | ||||
CD255, also known as TWEAK (TNF-related weak inducer of apoptosis), is a 27 kD protein and a tumor necrosis factor superfamily member 12 (TNFSF12). TWEAK is a type II transmembrane protein expressed on a variety of cell types. A soluble form of TWEAK is produced by proteolytic processing. TWEAK binds to the TWEAK receptor, FN14, to induce apoptosis, NF-κB translocation, and promote angiogenesis and endothelial cell proliferation. It has also been implicated in the induction of inflammatory cytokines.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant mouse CD255 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2927914 (BioLegend Cat. No. 119102)
Antigen Details
- Structure
- TNF superfamily member; type II membrane protein and secreted; homotrimer, 27 kD
- Distribution
-
Widely expressed; induced on activated CD4+ cells
- Function
- Weak inducer of apoptosis in some cell types, activates NF-κB, promotes angiogenesis and endothelial cell proliferation, induces inflammatory cytokine production
- Ligand/Receptor
- TWEAKR/FN14
- Cell Type
- T cells
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
- Chicheportiche Y, et al. 1997. J. Biol. Chem. 272:32401-10.
- Schneider P, et al. 1999. Eur. J. Immunol. 29:1785-92.
- Gene ID
- 21944 View all products for this Gene ID
- UniProt
- View information about CD255 on UniProt.org
Related FAQs
Other Formats
View All CD255 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse CD255 (TWEAK) | A19079J | FC |
| APC anti-mouse CD255 (TWEAK) | A19079J | FC |
| PE anti-mouse CD255 (TWEAK) | A19079J | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse CD255 (TWEAK)
Mouse TWEAK transfected cells were stained with purified ant... -
APC anti-mouse CD255 (TWEAK)
Mouse TWEAK transfected cells were stained with anti-mouse C... -
PE anti-mouse CD255 (TWEAK)
Mouse TWEAK transfected cells were stained with anti-mouse C...
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