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- Clone
- QA20A19 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD326, EGP40, MIC18, TROP1, KSA
- Isotype
- Rat IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
TE-71 (mouse thymic epithelial stromal cell line) cells were stained with purified anti-mouse CD326 (Ep-CAM) recombinant (clone QA20A19) (filled histogram), or purified rat IgG1, κ isotype control (open histogram), followed by PE goat anti-rat IgG.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 119002 | 100 µg | £81 | ||||
Ep-CAM (CD326) mediates calcium-independent homophilic cell to cell adhesion. It may also function as a growth factor receptor. It is thought to be involved in maintaining cells in position during proliferation. Expression of Ep-CAM seems to correlate inversely with the level of E-cadherin (CD324). Ep-CAM is considered to be important in tumor biology.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Recombinant
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone QA20B19 can completely block the binding of parental clone to target cells.
- RRID
-
AB_2936575 (BioLegend Cat. No. 119002)
Antigen Details
- Structure
- 40 kD single-pass type 1 glycoprotein. 293 amino acids, with a 21 aa signal peptide, a 246 aa extracellular domain, a 21 aa transmembrane domain, and a 26 aa cytoplasmic domain. The extracellular domain contains two epidermal growth factor-like repeats.
- Distribution
-
Expressed on majority of epithelial cell membranes with the exception of adult squamous cells of the skin and a few specific epithelial cell types
- Function
- Mediates calcium-independent homophilic cell-cell adhesion
- Interaction
- CD326 displays hemophilic binding
- Ligand/Receptor
- CD305 (LAIR-1), CD306 (LAIR-2), and Ep-CAM
- Antigen References
-
- Borkowski TA, et al. 1996. Eur J Immunol. 26:110-4.
- Bergsagel PL, et al. 1992. J Immunol. 148:590-6.
- Gene ID
- 17075 View all products for this Gene ID
- UniProt
- View information about CD326 on UniProt.org
Related FAQs
Other Formats
View All CD326 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse CD326 (Ep-CAM) Recombinant Antibody | QA20A19 | FC |
| PE anti-mouse CD326 (Ep-CAM) Recombinant Antibody | QA20A19 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse CD326 (Ep-CAM) Recombinant Antibody
TE-71 (mouse thymic epithelial stromal cell line) cells were... -
PE anti-mouse CD326 (Ep-CAM) Recombinant Antibody
TE-71 (mouse thymic epithelial stromal cell line) cells were...
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