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- Clone
- Duno85 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Tspan26, Tetraspanin-26
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
C57BL/6 mouse splenocytes were stained with purified CD37 (clone Duno85, filled histogram) or purified rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG FITC.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 146202 | 100 µg | £121 | ||||
CD37, also known as Tspan26 is a 40-60 kD member of the tetraspanin (TM4SF) family, with two extracellular regions and both termini in the cytoplasm. CD37 is highly expressed on mature B cells and is also expressed on T cells, monocytes, macrophages, and neutrophils, and dendritic cells to a lesser extent. CD37 forms complexes in the cell membrane with CD53, CD81, CD82, MHC class II and dectin 1. CD37 is essential for B cell survival, regulates T cell proliferation, IgA production, and is involved in dendritic cell migration. CD37 has been described as a promising target in the treatment of B cell malignancies.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Expression vector containing full length mouse CD37 gene
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2562284 (BioLegend Cat. No. 146202)
Antigen Details
- Structure
- Member of the tetraspanin (TM4SF) family, with two extracellular regions, both termini are cytoplasmic, 40-60 kD
- Distribution
- Highly expressed on B cells, low expression on T cells, monocytes, macrophages, neutrophils, and dendritic cells
- Function
- Essential for B cell survival, regulates T cell proliferation, regulates IgA production, involved in dendritic cell migration
- Cell Type
- B cells, Dendritic cells, Neutrophils
- Biology Area
- Immunology, Innate Immunity, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
-
1. Gartlan KH, et al. 2013. Eur. J. Immunol. 43:1208.
2. Annemiek B, et al. 2012. Sci. Signal. 5:82.
3. van Spriel AB. 2011. Biochem. Soc. Trans. 39:512.
4. Heider, KH, et al. 2012. Blood 118:4159. - Gene ID
- 12493 View all products for this Gene ID
- UniProt
- View information about CD37 on UniProt.org
Other Formats
View All CD37 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse CD37 | Duno85 | FC |
| PE anti-mouse CD37 | Duno85 | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse CD37
C57BL/6 mouse splenocytes were stained with purified CD37 (c... -
PE anti-mouse CD37
C57BL/6 mouse splenocytes were stained with CD45R/B220 APC a... 
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