Purified anti-mouse CD6 Antibody anti-CD6

Pricing & Availability

Clone: OX-129 (See other available formats)
Regulatory Status: RUO
Other Names: CD6/TP120
Isotype: Rat IgG2a, κ
Ave. Rating: Submit a Review
Product Citations: publications

OX-129_Purified_CD6_Antibody_FC_1_091213

Cat #

Size

Price

Quantity Check Availability

Save

146401

25 µg

£45

Check Availability

Need larger quantities of this item?
Request Bulk Quote

146402

100 µg

£77

Check Availability

Need larger quantities of this item?
Request Bulk Quote

Description

CD6, a 100 kD monomeric T cell surface glycoprotein, is a member of the scavenger receptor cysteine-rich protein superfamily. It is expressed on mouse thymocytes and splenic T cells and neurons, but not on splenic B cells. CD6 has a long cytoplasmic tail in mice, with two proline-rich domains that interact with the -SH3 domain binding sequence. CD6 binding to its ligand, CD166 (ALCAM), serves as a costimulatory molecule through its interaction with SLP-76. CD6 mediated signaling may contribute to thymocyte survival and functional avidity in mice and men.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2562492 (BioLegend Cat. No. 146401)
AB_2562492 (BioLegend Cat. No. 146402)

Antigen Details

Structure: 130 kD type I membrane protein belonging to the scavenger receptor cysteine-rich protein superfamily
Distribution: T cells, thymocytes, neurons
Function: Interaction with CD166 induces T cell proliferation and tyrosine phosphorylation.
Ligand/Receptor: CD166 (ALCAM)
Cell Type: Neurons, T cells, Thymocytes
Biology Area: Immunology, Innate Immunity
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Osorio LM, et al. 1995. Cell. Immunol. 166:44.
2. Whitney G, et al. 1995. Mol. Immunol. 32:89.
3. Starling GC, et al. 1996. Eur. J. Immunol. 26:738.
Gene ID: 12511 View all products for this Gene ID
UniProt: View information about CD6 on UniProt.org

Documentation

Reviews

Review This Product

Related Protocols

Cell Surface Flow Cytometry Staining Protocol

Related Products

Description	Clone	Applications

Related Pages & Pathways

Pathways

Related FAQs

There are no FAQs for this product.

Other Formats

View All CD6 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-mouse CD6	OX-129	FC
PE anti-mouse CD6	OX-129	FC

Certificate of Analysis

Go To Top Version: 1 Revision Date: 09/13/2013

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.