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- Clone
- OX-129 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD6/TP120
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 146401 | 25 µg | £45 | ||||
| 146402 | 100 µg | £77 | ||||
CD6, a 100 kD monomeric T cell surface glycoprotein, is a member of the scavenger receptor cysteine-rich protein superfamily. It is expressed on mouse thymocytes and splenic T cells and neurons, but not on splenic B cells. CD6 has a long cytoplasmic tail in mice, with two proline-rich domains that interact with the -SH3 domain binding sequence. CD6 binding to its ligand, CD166 (ALCAM), serves as a costimulatory molecule through its interaction with SLP-76. CD6 mediated signaling may contribute to thymocyte survival and functional avidity in mice and men.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2562492 (BioLegend Cat. No. 146401)
AB_2562492 (BioLegend Cat. No. 146402)
Antigen Details
- Structure
- 130 kD type I membrane protein belonging to the scavenger receptor cysteine-rich protein superfamily
- Distribution
-
T cells, thymocytes, neurons
- Function
- Interaction with CD166 induces T cell proliferation and tyrosine phosphorylation.
- Ligand/Receptor
- CD166 (ALCAM)
- Cell Type
- Neurons, T cells, Thymocytes
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Osorio LM, et al. 1995. Cell. Immunol. 166:44.
2. Whitney G, et al. 1995. Mol. Immunol. 32:89.
3. Starling GC, et al. 1996. Eur. J. Immunol. 26:738. - Gene ID
- 12511 View all products for this Gene ID
- UniProt
- View information about CD6 on UniProt.org
Other Formats
View All CD6 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse CD6 | OX-129 | FC |
| PE anti-mouse CD6 | OX-129 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-mouse CD6
-
PE anti-mouse CD6
C57BL/6 mouse splenocytes were stained with CD3 APC and anti... 
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