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Purified anti-mouse CD95 (Fas) Antibody

Pricing & Availability
Clone
SA367H8 (See other available formats)
Regulatory Status
RUO
Other Names
Fas, ALPS1A, APO-1, APT1
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
SA367H8_PURE_CD95_Antibody_101916
C57BL/6 thymocytes were stained with purified CD95 (clone SA367H8) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by PE anti-mouse IgG1.
  • SA367H8_PURE_CD95_Antibody_101916
    C57BL/6 thymocytes were stained with purified CD95 (clone SA367H8) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by PE anti-mouse IgG1.
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152602 500 µg £189
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Description

CD95, also known as Fas, is an approximately 45 kD type I transmembrane protein belonging to the TNFR superfamily (TNFRSF6). The expression of CD95 has been described in various organs, such as  thymus, spleen, liver, heart, lung and ovary. Upon ligand (FasL) binding, CD95 forms the death-inducing signaling complex (DISC) intracellularly and induce apoptosis of the cell. CD95-induced apoptosis plays important roles in development, as well as in maintining peripheral tolerance of the immune system.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Mouse Fas Transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Kobayashi A, et al. 2021. Front Immunol. 12:650856. PubMed
  2. Son YM, et al. 2020. Eur J Immunol. 50:1067. PubMed
  3. Mouat IC, et al. 2021. Elife. 10:. PubMed
  4. Wang J et al. 2018. Cell. 176(1-2):334-347 . PubMed
  5. Gubin MM, et al. 2018. Cell. 175:1014. PubMed
  6. Maier B, et al. 2020. Nature. 580:257. PubMed
RRID
AB_2629777 (BioLegend Cat. No. 152602)

Antigen Details

Structure
CD95 (Fas) is an approximately 45 kD type I transmembrane protein; cystiene-rich domain, death domain.
Distribution

Thymus, spleen, liver, heart, lung, and ovary.

Function
Induction of apoptosis.
Interaction
Caspase 8, caspase 10, CFLAR, FADD, PDCD6, SUMO1, and TNFRSF6.
Ligand/Receptor
FasL
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
Molecular Family
CD Molecules
Antigen References
  1. Ogasawara J, et al. 1995. J Exp Med. 181:485-91.
  2. Ogasawara J, et al. 1993. Nature. 364:806-9.
  3. Nishimura Y, et al. 1995. J Immunol. 154:4395-403.
Gene ID
14102 View all products for this Gene ID
UniProt
View information about CD95 on UniProt.org
Go To Top Version: 2    Revision Date: 10/19/2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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