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- Clone
- MH7E7 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Clec4a1, DCIR4, Dcir4, dendritic cell inhibitory receptor 4
- Isotype
- Rat IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
C57BL/6 bone marrow were surface stained with CD11b FITC and purified DCIR4 (Clec4a1) (clone MH7E7) (left) or purified rat IgG1, κ isotype control (right), followed by anti-rat IgG1, κ PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 162002 | 500 µg | £398 | ||||
Clec4a1 or dendritic cell inhibitory receptor 4 (DCIR4) is a C-type lectin receptor (CLR) which belongs to DC immunoreceptor (DCIR) family. Inhibitory members of DCIR family are type II membrane glycoprotein consisting of a carbohydrate recognition domain (CDR) on their COOH terminus and immunoreceptor tyrosin-based inhibitory motifs (ITIM) on their intracellular domain. Studies indicate that inhibitory DCIRs play an anti-inflammatory role and that immunopathology related to rheumatoid arthritis and TB infection is driven by their loss. Inhibitory DCIR are found on DCs, B cells, monocytes, macrophages, and neutrophils, but not T or NK cells and relay signal through Src homology region 2 domain-containing phosphatase (SHP). DCIR4, yet to be confirmed to have inhibitory role, is exclusive to non-granulocytic myeloid cells and its expression level can be used to differentiate between patrolling and inflammatory monocytes.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- DCIR4 reporter cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2888810 (BioLegend Cat. No. 162002)
Antigen Details
- Structure
- Type II membrane glycoprotein consisting of a carbohydrate recognition domain (CDR) on their COOH terminus and immunoreceptor tyrosin-based inhibitory motifs (ITIM) on their intracellular domain
- Cell Type
- B cells, Dendritic cells, Macrophages, Monocytes, Neutrophils
- Biology Area
- Adaptive Immunity, Immunology, Inhibitory Molecules, Innate Immunity
- Molecular Family
- Innate Immune Signaling
- Antigen References
-
1. Kameda Y, et al. 2016. Biochem. Biophys. Res. Commun. 480: 215-221
2. Hsu Y, et al. 2017. Biochem. Biophys. Res. Commun. 494: 440-445 - Gene ID
- 269799 View all products for this Gene ID
- UniProt
- View information about DCIR4 on UniProt.org
Related FAQs
Other Formats
View All Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse DCIR4 (Clec4a1) Antibody | MH7E7 | FC |
| PE anti-mouse DCIR4 (Clec4a1) Antibody | MH7E7 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse DCIR4 (Clec4a1) Antibody
C57BL/6 bone marrow were surface stained with CD11b FITC and... -
PE anti-mouse DCIR4 (Clec4a1) Antibody
C57BL/6 bone marrow cells were surface stained with CD11b FI...
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