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Purified anti-mouse IL-23R Antibody

Pricing & Availability
Clone
12B2B64 (See other available formats)
Regulatory Status
RUO
Other Names
Interleukin 23 Receptor, IL-23 Receptor, IL-23R, IBD17
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
12B2B64_Pure_IL-23R_Antibody_123015
Th17-polarized cells from C57BL/6 mouse lymph nodes were stained with purified IL-23R (clone 12B2B64) (filled histogram) or purified rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG PE.
  • 12B2B64_Pure_IL-23R_Antibody_123015
    Th17-polarized cells from C57BL/6 mouse lymph nodes were stained with purified IL-23R (clone 12B2B64) (filled histogram) or purified rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG PE.
  • 12B2B64_Pure_IL-23R_Antibody_supplemental_052417
    IL-6 stimulated (3 days) C57BL/6 splenocytes were stained with purified IL-23R (clone 12B2B64, filled histogram) or purified rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG2b FITC.
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150902 100 µg £189
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Description

IL-23R is a 72 kD protein that associates with IL-12RB1 to form a heterodimer. It is a ligand for IL-23 and stimulates T, NK and some myeloid cells.  It is necessary for generation of Th17 cells but is not required for maintenance of previously generated Th17 cells.  Expression of IL-23R or mutations in the IL23R gene has been associated with autoimmunity and may also be important in tumor biology.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Partial mouse IL-23R recombinant protein (aa 24-374)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.75 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Tsai CM, et al. 2019. J Innate Immun. 333:12. PubMed
  2. Noll J, et al. 2016. J Hepatol. 64:1147-1157. PubMed
RRID
AB_2566431 (BioLegend Cat. No. 150902)

Antigen Details

Structure
72 kD protein that associates with IL-12RB1 to form a heterodimer.
Function
Involved in IL-23A signaling.
Interaction
JAK2 and STAT3.
Ligand/Receptor
IL-23/IL23A.
Biology Area
Immunology
Molecular Family
Cytokine/Chemokine Receptors
Antigen References

1. Parham C, et al. 2002. J. Immunol. 168:5699.
2. Schmechel S, et al. 2008. Inflamm. Bowel Dis. 14:204.
3. Harris TJ, et al. 2007. J. Immunol. 179:4313.
4. Zhang XY, et al. 2006. Immunogenetics 57:934.
5. Awasthi A, et al. 2009. J. Immunol. 182:5904.

Gene ID
209590 View all products for this Gene ID
UniProt
View information about IL-23R on UniProt.org
Go To Top Version: 1    Revision Date: 01/05/2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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