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- Clone
- RMT2-1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- T cell immunoglobulin and mucin domain containing protein-2
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 119602 | 500 µg | £269 | ||||
Tim-2 is a transmembrane protein known as T cell immunoglobulin and mucin domain containing protein-2. It is expressed on activated T cells and preferentially on differentiated Th2 cells. Sema4A is the ligand of Tim-2. A blockade of Tim-2/Tim-2 ligand interaction results in T cell hyperproliferation and Th2 cytokine production. Tim-2 plays a critical role in the development of atopic disease and other Th2-biased immune responses.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance in each application.
-
Application References
(PubMed link indicates BioLegend citation) -
- Nakae S, et al. 2007. Blood doi:10.1182/blood-2006-11-058800.
- RRID
-
AB_345372 (BioLegend Cat. No. 119602)
Antigen Details
- Structure
- Transmembrane protein containing immunoglobulin domain and mucin-like domain; predicted molecular weight 33 kD
- Distribution
- Developmentally regulated; highly expressed in embryonic development at the 8-cell stage and blastocyst. Expressed on activated T lymphocytes.
- Function
- Plays a critical role in immune responses and the development of atopic diseases
- Ligand/Receptor
- Binds to Sema4A
- Cell Type
- T cells, Embryonic Stem Cells
- Biology Area
- Immunology, Stem Cells
- Molecular Family
- CD Molecules
- Antigen References
-
1. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454.
2. Kumanogoh A, et al. 2002. Nature 419:629.
3. Chakravarti S, et al. 2005. J. Exp. Med. 202:437. - Gene ID
- 171284 View all products for this Gene ID
- UniProt
- View information about Tim-2 on UniProt.org
Related FAQs
Other Formats
View All Tim-2 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse Tim-2 | RMT2-1 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse Tim-2
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