- Clone
- Prk 8 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- PARK2, AR-JP, LPRS2, PDJ, PRKN, E3 ubiquitin-protein ligase parkin, Parkin 2, E3 ubiquitin ligase, parkinson disease protein 2, parkinson juvenile disease protein 2, Parkinson disease (autosomal recessive, juvenile) 2, parkin
- Previously
-
Signet Catalog# 9530-02
Signet Catalog# 9530-05
Signet Catalog# 9530-10
Covance Catalog# SIG-39530
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Parkin (also known as PARK2, AR-JP, PRKN) is a protein encoded by the PARK2 gene in humans. It is a component of the E3 ubiquitin ligase complex that mediates the targeting of proteins for degradation. Mutations in the PARK2 gene cause a familial form of Parkinson’s disease called autosomal recessive juvenile Parkinson’s disease (AR-JP).
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution (no preservatives or carrier proteins).
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.
- Application
-
WB - Quality tested
ICC, IHC-P - Reported in the literature, not verified in house - Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This antibody is reactive to the R2 domain of human and murine parkin.
-
Application References
(PubMed link indicates BioLegend citation) -
- Tay SP, et al. 2018. J Biol Chem. 285: 29231-29238. (WB, ICC)
- Pawlyk AC, et al. 2003. J Biol Chem. 278(48):48120-8. (WB, IHC-P)
- RRID
-
AB_2564743 (BioLegend Cat. No. 808504)
AB_2564743 (BioLegend Cat. No. 808501)
AB_2564743 (BioLegend Cat. No. 808502)
AB_2564743 (BioLegend Cat. No. 808503)
Antigen Details
- Biology Area
- Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Protein Trafficking and Clearance
- Molecular Family
- Mitochondrial Markers
- Gene ID
- 5071 View all products for this Gene ID
- UniProt
- View information about Parkin on UniProt.org
Related FAQs
Other Formats
View All Parkin Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Parkin | Prk 8 | WB,ICC,IHC-P |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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