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Purified anti-rat CD314 (NKG2D) Antibody

Pricing & Availability
Clone
11D5C9 (See other available formats)
Regulatory Status
RUO
Other Names
KLRK1, NKR2
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
11D5C9_PURE_CD314_Antibody_052020
Lewis rat splenocytes were stained with CD161 APC and purified CD314 (clone 11D5C9) (left) or purified mouse IgG1, κ isotype control. (right), followed by anti-mouse IgG PE.
  • 11D5C9_PURE_CD314_Antibody_052020
    Lewis rat splenocytes were stained with CD161 APC and purified CD314 (clone 11D5C9) (left) or purified mouse IgG1, κ isotype control. (right), followed by anti-mouse IgG PE.
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206302 100 µg £197
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Description

NKG2D is a lectin-like type II transmembrane protein also known as CD314. It is expressed on NK cells and a subset of T lymphocytes. NKG2D serves as a stimulatory receptor to activate NK cells via the non-covalently associated DAP10 or DAP12 adaptor. Rat NKG2D has been reported to induce the synthesis of IFN gamma and induce cytotoxicity in response to rat RAE1L and PRLT, RAE family members in rat. NKG2D is also involved in liver allograft rejection.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Rat NKG2D fused with human Fc
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2860758 (BioLegend Cat. No. 206302)

Antigen Details

Structure
A lectin-like type II transmembrane protein
Distribution

NK cells and a subset of T lymphocytes

Function
A stimulatory receptor to activate NK cells by association with DAP10 or DAP12 adaptor
Ligand/Receptor
RAE1L and PRLT
Cell Type
NK cells, NKT cells, T cells
Biology Area
Adaptive Immunity, Immunology
Molecular Family
CD Molecules, Immune Checkpoint Receptors, Innate Immune Signaling
Antigen References
  1. Obara H, et al. 2005. Am. J. Transplant. 5:2094-103.
  2. Raulet DH. 2003. Nat. Rev. Immunol. 3:781-790.
  3. Sun Z, et al. 2009. Hepatology. 49:587-597.
  4. Dissen E, et al. 1996. J. Exp. Med.183:2197-2207.
  5. Løvik G, et al. 1995. J. Immunol. Methods. 179:59-69.
  6. Ming Z, et al. 2010. Eur. J. Immunol. 40:1748-1757.
Gene ID
24934 View all products for this Gene ID
UniProt
View information about CD314 on UniProt.org
Go To Top Version: 1    Revision Date: 05/20/2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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