- Clone
- MHN3-21 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Neurogenic locus notch homolog protein 3, Notch-3, CADASIL
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
345409 | 25 tests | 120€ | ||||
345410 | 100 tests | 261€ |
The Notch receptors are highly conserved from invertebrates to mammals. While Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences. The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus. This translocation triggers a series of signaling processes. Notch 3 is primarily expressed in adult arterial smooth muscle cells. Notch3 gene mutation can cause CADASIL, a hereditary early stroke syndrome.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human Notch 3-human IgG1 Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
-
Red Laser (633 nm)
- Product Citations
-
- RRID
-
AB_2564483 (BioLegend Cat. No. 345409)
AB_2564483 (BioLegend Cat. No. 345410)
Antigen Details
- Structure
- Transmembrane receptor, heterodimer consisting of a C-terminal fragment and N-terminal fragment probably linked by disulphide bonds. Contains 5 ankyrin repeats, 29-36 EGF repeats, 3 Notch/Lin repeats.
- Cell Type
- Tregs
- Biology Area
- Immunology
- Antigen References
-
1. Ehebauer ME. et al. 2006. Biochem J 392:13
2. Joutel A et al. 1996. Nature 383:707
3. Shimizu K et al. 2000. Mol Cell Biology 20:18
4. Tanigaki K et al. 2007. Nature Immunol 8:451
5. Bellavia D et al. 2008. 27:5092
6. Louvi A et al. Dev Neurosci. 2006. 28:5 - Gene ID
- 4854 View all products for this Gene ID
- UniProt
- View information about Notch 3 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All Notch 3 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human Notch 3 | MHN3-21 | FC |
PE anti-human Notch 3 | MHN3-21 | FC |
Purified anti-human Notch 3 (Maxpar® Ready) | MHN3-21 | FC,CyTOF® |
APC anti-human Notch 3 | MHN3-21 | FC |
TotalSeq™-A0233 anti-human Notch 3 | MHN3-21 | PG |
TotalSeq™-B0233 anti-human Notch 3 | MHN3-21 | PG |
TotalSeq™-C0233 anti-human Notch 3 | MHN3-21 | PG |
Customers Also Purchased
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human Notch 3
Human T cell leukemia cell line HPB-ALL stained with MHN3-21... -
PE anti-human Notch 3
Human T cell leukemia cell line HPB-ALL stained with MHN3-21... -
Purified anti-human Notch 3 (Maxpar® Ready)
Human Jurkat T cells (top) and human NALM-6 pre-B cells (bot... -
APC anti-human Notch 3
HPB-ALL, human T cell leukemia cell line was stained with No... -
TotalSeq™-A0233 anti-human Notch 3
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TotalSeq™-B0233 anti-human Notch 3
-
TotalSeq™-C0233 anti-human Notch 3
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