Biotin anti-human CD55 Antibody anti-CD55

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Clone: JS11 (See other available formats)
Regulatory Status: RUO
Workshop: VI N-L060
Other Names: DAF (Decay Accelerating Factor)
Isotype: Mouse IgG1, κ
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Product Citations: publications

JS11_Biotin_070207 — Human peripheral blood lymphocytes stained with biotinylated JS11, followed by Sav-PE

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311304

100 µg

151€

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Description

CD55 is a 60-70 kD glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein also known as decay-accelerating factor (DAF). It is expressed on hematopoietic cells including erythrocytes and many non-hematopoietic cells. CD55 accelerates the dissociation of the components of the C3-convertases (namely C2a from C4b in the C4bC2a complex, a C3-convertase of the classical pathway, and factor Bb from the C3bBb complex, a C3-convertase of the alternative pathway) to protect cells from inappropriate damage caused by autologous complement. CD55 has been reported to reduce the efficiency of NK cell lysis and induce signal transduction in T cells. CD55 has also been shown to interact with CD97 and bind to Coxsackie and Echovirus.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Reported Reactivity: African Green, Baboon, Cynomolgus
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_314861 (BioLegend Cat. No. 311304)

Antigen Details

Structure: GPI-achored regulator of complement activation (RCA), type I membrane glycoprotein, 60-70 kD
Distribution: Hematopoietic cells including erythrocytes and many non-hematopoietic cells
Function: Protects against inappropriate complement activation and cell damage, induces signal transduction, reduces the efficiency of NK cell lysis
Ligand/Receptor: C3b, C4b, CD97, Coxsackie viruses
Biology Area: Cell Biology, Costimulatory Molecules, Immunology, Neuroinflammation, Neuroscience
Molecular Family: CD Molecules
Antigen References: 1. Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.
2. Hamann J, et al. 1996. J. Exp. Med. 184:1185.
3. Fujita T, et al. 1987. J. Exp. Med. 166:1221
Gene ID: 1604 View all products for this Gene ID
UniProt: View information about CD55 on UniProt.org

Documentation

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Related Protocols

Cell Surface Flow Cytometry Staining Protocol

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Related Pages & Pathways

Pathways

Related FAQs

How many biotin molecules are per antibody structure?: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.

Other Formats

View All CD55 Reagents Request Custom Conjugation

Description	Clone	Applications
APC anti-human CD55	JS11	FC
Biotin anti-human CD55	JS11	FC
FITC anti-human CD55	JS11	FC
PE anti-human CD55	JS11	FC
Purified anti-human CD55	JS11	FC
PE/Cyanine7 anti-human CD55	JS11	FC
PerCP/Cyanine5.5 anti-human CD55	JS11	FC
TotalSeq™-A0383 anti-human CD55	JS11	PG
TotalSeq™-C0383 anti-human CD55	JS11	PG
TotalSeq™-B0383 anti-human CD55	JS11	PG

Certificate of Analysis

Go To Top Version: 1 Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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