- Clone
- A17082A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- β2M, β2-M, beta2-microglobulin b2-M, b2M
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
395721 | 25 tests | 151€ | ||||
395722 | 100 tests | 334€ |
β2-microglobulin (β2M) is a 12 kD nonpolymorphic Ig like protein. It is a non-membrane-anchored glycoprotein and is noncovalently associated with 39-44 kD polymorphic heavy chains of MHC class I molecules to form HLA class I antigen complex. In association with HLA class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role both in governing MHC class I molecules stability and in promoting antigen binding and presenting the antigen to CD3/TCR complex of CD8+ T cells.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human Beta2-microglobulin
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE/Cyanine5 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
-
Clone A17082A partially cross-blocks anti-human ß2-microglobulin clone 2M2 and does not block anti-human HLA-A,B,C clone W6/32 staining, based on in-house testing.
- RRID
-
AB_3083392 (BioLegend Cat. No. 395721)
AB_3083392 (BioLegend Cat. No. 395722)
Antigen Details
- Structure
- 12 KD, Ig like structure
- Distribution
-
Leukocytes, platelets, endothelial cells, epithelial cells and other nucleated cells.
- Function
- Form MHC class I
- Interaction
- MHC class I heavy chain and other MHC I like molecules.
- Cell Type
- Antigen-presenting cells, Endothelial cells, Epithelial cells, Leukocytes, Platelets
- Biology Area
- Cancer Biomarkers, Immunology, Innate Immunity
- Molecular Family
- MHC Antigens
- Antigen References
-
- Engelhard VH. 1994. Curr. Opin. Immunol. 6:13.
- Williams DB, et al. 1989. J. Immunol. 142:2796.
- Danliczyk UG and TL. Delovitch. 1994. J. Immunol. 153:3533.
- Williams A, et al. 2002. Tissue Antigens. 59:3.
- Gene ID
- 567 View all products for this Gene ID
- UniProt
- View information about beta2-microglobulin on UniProt.org
Related FAQs
Other Formats
View All beta2-microglobulin Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human β2-microglobulin | A17082A | FC |
FITC anti-human β2-microglobulin | A17082A | FC |
Alexa Fluor® 700 anti-human β2-microglobulin | A17082A | FC |
APC/Fire™ 750 anti-human β2-microglobulin | A17082A | FC |
PE anti-human β2-microglobulin | A17082A | FC |
APC anti-human β2-microglobulin | A17082A | FC |
PE/Cyanine7 anti-human β2-microglobulin | A17082A | FC |
PerCP/Cyanine5.5 anti-human β2-microglobulin | A17082A | FC |
APC/Cyanine7 anti-human β2-microglobulin | A17082A | FC |
Biotin anti-human β2-microglobulin | A17082A | FC |
PE/Cyanine5 anti-human β2-microglobulin | A17082A | FC |
PE/Dazzle™ 594 anti-human β2-microglobulin | A17082A | FC |
Spark UV™ 387 anti-human β2-microglobulin | A17082A | FC |
Brilliant Violet 421™ anti-human β2-microglobulin | A17082A | FC |
Spark Red™ 718 anti-human β2-microglobulin | A17082A | FC |
Pacific Blue™ anti-human β2-microglobulin | A17082A | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with purifie... -
FITC anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with anti-hu... -
Alexa Fluor® 700 anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with anti-hu... -
APC/Fire™ 750 anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with anti-hu... -
PE anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with β2-micr... -
APC anti-human β2-microglobulin
Human peripheral blood lymphocytes was stained with anti-hum... -
PE/Cyanine7 anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with anti-hu... -
PerCP/Cyanine5.5 anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with anti-hu... -
APC/Cyanine7 anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with anti-hu... -
Biotin anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with biotiny... -
PE/Cyanine5 anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with anti-hu... -
PE/Dazzle™ 594 anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with anti-hu... -
Spark UV™ 387 anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with anti-hu... -
Brilliant Violet 421™ anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with anti-hu... -
Spark Red™ 718 anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with anti-hu... -
Pacific Blue™ anti-human β2-microglobulin
Human peripheral blood lymphocytes were stained with anti-hu...
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