- Clone
- CPTC-Fascin1-2 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- FASN1, 55 kDa actin-bundling protein, Singed-like protein, p55
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
868301 | 25 µg | 85€ | ||||
868302 | 100 µg | 221€ |
Fascin is a 55 kD F-actin binding protein that is involved in cell motility and migration. Fascin plays an important role in the organization and formation of membrane ruffles, stress fibers, and a diverse set of cell protrusions, such as filopodia. In the mouse subventricular zone-derived migratory neuroblasts, Fascin is highly upregulated to guide the migration of cells along the rostral migratory stream. In Drosophila, Fascin controls neuronal class-specific dendrite arbor morphology to elicit the accurate establishment of neuronal circuits.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human Fascin full-length protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2820172 (BioLegend Cat. No. 868301)
AB_2820172 (BioLegend Cat. No. 868302)
Antigen Details
- Structure
- Human Fascin is a 493 amino acid protein with a molecular mass of 54 kD.
- Distribution
-
Tissue distribution: Ubiquitously expressed
Cellular distribution: Cytosol, cytoskeleton, and stress fibers - Function
- Fascin is involved in the assembly of filamentous actin.
- Interaction
- Fascin interacts with RUFY3, beta-catenin, and PLXNB3.
- Cell Type
- Neurons
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure, Neurodegeneration, Neuroscience
- Molecular Family
- Cytoskeletal Proteins
- Antigen References
-
- Yamashiro S, et al. 1998. Mol Biol Cell. 9(5): 993-1006.
- Nagel J, et al. 2012. Development 139, 2999-3009
- Sonego M, et al. 2013. J Neurosci. 33(30): 12171–85.
- Gene ID
- 6624 View all products for this Gene ID
- UniProt
- View information about Fascin-1 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Fascin-1 | CPTC-Fascin1-2 | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-Fascin-1
Western blot of purified anti-Fascin-1 antibody (clone CPTC-...
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