- Clone
- W18172E (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Filamin A, Endothelial Actin-Binding Protein, Actin Binding Protein 280, Non-Muscle Filamin, Filamin A Alpha, Alpha-Filamin, Filamin-1, Filamin-A, ABP-280, FLN-A, FLN1, FLN, Filamin A Alpha (Actin Binding Protein 280),
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
937701 | 25 µg | 81€ | ||||
937702 | 100 µg | 203€ |
Filamin A is an actin binding protein which crosslinks actin filaments into an orthogonal network and helps anchor membrane glycoproteins to cytoskeleton. Filamin A is also important in modifying cell shape in cell migration by changing the cytoskeleton. Filamin A is involved in ciliogenesis, cell adhesion and in the development of blood vessels, and other organs. Diseases associated with Filamin A include Melnick-Needles syndrome, otopalatodigital syndrome, periventricular nodular heterotopias and frontometaphyseal dysplasia.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Partial recombinant human Filamin A
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
KO/KD-WB, ICC - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.0625 - 1.0 µg/mL. For immunocytochemistry, a concentration range of 2.0 - 5.0 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone recognizes human and mouse Filamin A.
Clone works well in ICC when cells are permeabilized with either Triton X-100 or methanol.
Clone is not recommended for IP. - RRID
-
AB_2876755 (BioLegend Cat. No. 937701)
AB_2876755 (BioLegend Cat. No. 937702)
Antigen Details
- Structure
- Filamin A is a 2647 amino acid protein with a predicted molecular weight of 281 kD.
- Distribution
-
Filamin A is primarily localized in the actin filaments, plasma membrane and cytosol.
- Function
- Actin binding protein
- Interaction
- Actin, FLNB
- Molecular Family
- Cytoskeletal Proteins
- Antigen References
-
- Feng Y, et al. 2006. Proc Natl Acad Sci U S A. 103:19836-41.
- Patel-Hett S, et al. 2011. Blood. 118:1641-52.
- Sun Y, et al. 2010. Am J Hum Genet. 87:146-53.
- Foley C, et al. 2010. Mol Syndromol. 1:121-126.
- Gene ID
- 2316 View all products for this Gene ID
- UniProt
- View information about Filamin A on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All Filamin A Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Filamin A | W18172E | WB,KO/KD-WB,ICC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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