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- Clone
- A22092I (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TNFRSF1B, p75, p75TNFR, TNFR2, TNFR80, TBPII
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood mononuclear cells were stained with purified anti-human CD120b (clone A22092I) (left), or purified mouse IgG2b, κ isotype control (right) followed by anti-mouse IgG PE. Cells were then stained with anti-human CD3 (clone UCHT1) Brilliant Violet 421™. Data shown was gated on lymphocytes.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 312405 | 100 µg | 90€ | ||||
CD120b, also known as TNFRII or TNFRSF1B, belongs to the TNF receptor superfamily and can interact with ligands TNF-α and TNF-β (also known as LT-α). It is a 75 kD type I transmembrane protein expressed on lymphocytes, monocytes, and granulocytes. When present in a heterocomplex with CD120a, it induces the recruitment of anti-apoptotic molecules, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Mutations in CD120b are associated with TNF-associated periodic syndrome (TRAPS) or periodic fever syndrome.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- CD120b recombinant protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details
- Structure
- 75 kD, type I transmembrane protein, member of the TNF-receptor superfamily, forms a heterocomplex with TNFRI
- Distribution
-
Expressed on cells of hematopoietic lineage including monocytes, lymphocytes, and granulocytes
- Function
- When complexed with TNFRI, recruits anti-apoptotic molecules c-IAP1 and c-IAP2 which possess E3 ubiquitin ligase activity; cysteine rich extracellular region
- Interaction
- Interacts with TTRAP and TRAF2
- Ligand/Receptor
- TNF-α and TNF-β (LT-α)
- Cell Type
- Granulocytes, Lymphocytes, Monocytes
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Transcription Factors
- Molecular Family
- CD Molecules
- Antigen References
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- Andrews JS, et al. 1990. J Immunol. 144:2582-91.
- Nophar Y, et al. 1990. EMBO J. 9:3269-78.
- Kohno T, et al. 1990. Proc Natl Acad Sci USA. 87:8331.
- Tartaglia LA, et al. 1991. Proc Natl Acad. Sci USA. 88:9292.
- Hijdra D, et al. 2012. J Inflamm (Lond). 9:38.
- Chen X, et al. 2013. J Immunol. 190:1076-84.
- Gene ID
- 7133 View all products for this Gene ID
- UniProt
- View information about CD120b on UniProt.org
Related FAQs
Other Formats
View All CD120b Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD120b | A22092I | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD120b
Human peripheral blood mononuclear cells were stained with p...
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