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Purified anti-human CD210b (IL-10RB) Antibody

Pricing & Availability
Clone
S17009F (See other available formats)
Regulatory Status
RUO
Other Names
Interleukin 10 receptor subunit beta, CRFB4, CRF2-4, D21S58, D21S66, CDW210B
Isotype
Mouse IgG2a, κ
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Product Citations
publications
S17009F_Purified_CD210b_Antibody_2_051419.png
Human peripheral blood lymphocytes were stained CD210B (IL-10RB) (clone S17009F) Purified (left) or Mouse IgG2a, κ isotype control Purified (right), followed by anti-mouse IgG2a PE and HLA-DR PerCP.
  • S17009F_Purified_CD210b_Antibody_2_051419.png
    Human peripheral blood lymphocytes were stained CD210B (IL-10RB) (clone S17009F) Purified (left) or Mouse IgG2a, κ isotype control Purified (right), followed by anti-mouse IgG2a PE and HLA-DR PerCP.
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396802 100 µg 113€
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Description

CD210b is a Type 1 transmembrane glycoprotein also known as, subunit 2 (IL-10R2) and is an essential chain for the IL-10 receptor complex. The IL-10 receptor complex is made up of alpha (IL10-RA) and beta (IL-10RB) subunits. Coexpression of these subunits has been shown to be required for IL10 induced signal transduction. Binding of dimeric IL-10 to two alpha subunits can cause the recruitment of two beta subunits resulting in the transduction of the intracellular JAK/STAT pathway.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human IL10RB-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

RRID
AB_2810606 (BioLegend Cat. No. 396802)

Antigen Details

Structure
Type 1 transmembrane glycoprotein belonging to the cytokine receptor family.
Distribution

CD210b is expressed by a variety of cell types including T cells, B cells, NK cells, monocytes and macrophages.

Function
Activates STAT1, STAT3, Jak1, Tyk and is a component of cytokine receptor complexes specific for IL-22, IL-26, IL-28, and IL-29.
Ligand/Receptor
IL-10
Cell Type
B cells, Macrophages, NK cells, T cells, Thymocytes
Biology Area
Adaptive Immunity, Immunology, Signal Transduction
Molecular Family
Cytokine/Chemokine Receptors
Antigen References
  1. Donnelly RP, et al. 2004. J Leukoc Biol. 76(2):314-321.  
  2. Koppelman B, et al. 1997. Immunity. (6): 861-871
  3. Kotenko SV, et al. 1997. EMBO J. 16(19):5894-5903. 
  4. Liu Y, et al. 1995. J Immunol. 152(4):1821-1829.
Gene ID
3588 View all products for this Gene ID
UniProt
View information about CD210b on UniProt.org
Go To Top Version: 1    Revision Date: 05/14/2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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