- Clone
- HY101 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Platelet glycoprotein VI, GPVI
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
383802 | 100 µg | 199€ |
Glycoprotein VI (GPVI) is a 37 kD type-I transmembrane glycoprotein of the immunoglobulin superfamily, primarily expressed on platelets and megakaryocytes. GPVI is a collagen receptor and is involved in collagen-induced platelet adhesion and activation. GPVI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Glycoprotein VI transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
Agonist, WB - Reported in the literature, not verified in house - Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
-
- Chen, H, et al. 2001. J Biol chem. 277: 3011-3019. (FC, WB)
- van Dievoet, M, et al. 2022. Platelets. 1,17:1-4. (Agonist)
- RRID
-
AB_2924586 (BioLegend Cat. No. 383802)
Antigen Details
- Structure
- Type-I transmembrane glycoprotein, 37 kD, member of the immunoglobulin superfamily,
- Distribution
-
Megakaryocytes, Platelets
- Function
- Platelet adhesion and activation, blood coagulation, and hemostasis
- Interaction
- FcR gamma-chain, Src kinases, SYK, LAT
- Ligand/Receptor
- Collagen
- Gene ID
- 51206 View all products for this Gene ID
- UniProt
- View information about GP6 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All GP6 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human GP6 | HY101 | FC,Agonist,WB |
Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human GP6
Human peripheral blood platelets were stained with anti-huma...
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