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Purified anti-human VISTA (PD-1H) Antibody

Pricing & Availability
Clone
A17002B (See other available formats)
Regulatory Status
RUO
Other Names
V-Set Immunoregulatory Receptor (VSIR), B7H5, GI24, B7-H5, Dies1, PD-1H, SISP1, VISTA, PP2135, C10orf54, DD1alpha
Isotype
Mouse IgG2b, κ
Ave. Rating
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Product Citations
publications
A17002B_Pure_VISTA_Antibody_012521
Human peripheral blood monocytes were stained with purified anti-human VISTA (PD-1H) (clone A17002B) (filled histogram) or purified mouse IgG2b, κ isotype control (open histogram). Cells were then stained with goat anti-mouse IgG PE.
  • A17002B_Pure_VISTA_Antibody_012521
    Human peripheral blood monocytes were stained with purified anti-human VISTA (PD-1H) (clone A17002B) (filled histogram) or purified mouse IgG2b, κ isotype control (open histogram). Cells were then stained with goat anti-mouse IgG PE.
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378102 100 µg 272€
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Description

VISTA (V-domain Ig suppressor of T cell activation), also known as PD-1H, is a type I transmembrane protein with a single extracellular IgV domain. VISTA is expressed by a subset of T cells, macrophages, dendritic cells, neutrophils, and NK cells. It was reported that in certain tumor environment, there is low-pH dependent interaction between VISTA and PSGL1. However, the physiological binding partner for VISTA and the mechanism of its action are not clearly understood. VISTA is considered as a checkpoint regulator and a promising target for cancer immunotherapy.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human VISTA protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC – Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2910435 (BioLegend Cat. No. 378102)

Antigen Details

Structure
Ig V-domain like
Distribution

Hematopoietic cells, monocytes, macrophages, dendritic cell, granulocytes, subsets of T cells

Function
Suppressing T cell activation
Cell Type
Dendritic cells, Granulocytes, Lymphocytes, Macrophages, Monocytes, T cells
Biology Area
Immunology, Inhibitory Molecules
Antigen References
  1. Wang Li, et al. 2011. J Exp Med. 208:577-92.
  2. Nowak EC, et al. 2017. Immunol Rev. 276:66-79.
  3. Flies DB, et al. 2014. J Clin Invest. 124:1966-75.
Gene ID
64115 View all products for this Gene ID
UniProt
View information about VISTA on UniProt.org
Go To Top Version: 1    Revision Date: 01/25/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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