- Clone
- H5/FcRL3 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Fc receptor-like 3 (FCRL3), Immune receptor translocation-associated protein 3 (IRTA3), SH2 domain-containing phosphatase anchor protein 2 (SPAP2), IFGP family protein 3 (IFGP3)
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
374403 | 100 µg | 199€ | ||||
374404 | 1 mg | 572€ |
Select size of product is eligible for a 40% discount! Promotion valid until December 31, 2024. Exclusions apply. To view full promotion terms and conditions or to contact your local BioLegend representative to receive a quote, visit our webpage.
CD307c is a type 1 transmembrane glycoprotein in the FcRL family of the Ig gene superfamily that is conserved in humans and not found in mice. It is expressed on NK cells, T cell, regulatory T cell, B cell and plasma cell subsets. Intracellular ITAM and ITIM motifs in conjunction with extracellular Ig domains are thought to play a role in the regulation of immune response, and autoimmune function. Impairment of normal FcRL3 function has been linked to systemic lupus erythematosus, rheumatoid arthritis, and autoimmune thyroid disease.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- FcRL3 full length expression plasmid DNA, followed by cell boost using transiently transfected cells with the same plasmid.
- Formulation
- 0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
- Endotoxin Level
- Less than 0.01 EU/µg of the protein (< 0.001 ng/µg of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 μg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
-
- Nagata S, et al. 2009. J. Immunol. 182:7518-26.
- RRID
-
AB_2715834 (BioLegend Cat. No. 374403)
AB_2715834 (BioLegend Cat. No. 374404)
Antigen Details
- Distribution
-
NK, T, regulatory T, B, and plasma cell subsets.
- Interaction
- Tyrosine-protein phosphatase non-receptor type 6 (PTPN6).
- Cell Type
- B cells, NK cells, Plasma cells, T cells, Tregs
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Fc Receptors
- Antigen References
-
1. Bin Dhuban K, et al. 2015. J. Immunol. 194(8):3687-96.
2. Yuan M, et al. 2016. Mol. Neurobiol. 53:2029-35.
3. Fang Y, et al. 2016. Immunobiology. 221(1):56-62. - Gene ID
- 115352 View all products for this Gene ID
- UniProt
- View information about CD307c/FcRL3 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
- Do you guarantee that your antibodies are totally pathogen free?
-
BioLegend does not test for pathogens in-house aside from the GoInVivo™ product line. However, upon request, this can be tested on a custom basis with an outside, independent laboratory.
- Does BioLegend test each Ultra-LEAF™ antibody by functional assay?
-
No, BioLegend does not test Ultra-LEAF™ antibodies by functional assays unless otherwise indicated. Due to the possible complexities and variations of uses of biofunctional antibodies in different assays and because of the large product portfolio, BioLegend does not currently perform functional assays as a routine QC for the antibodies. However, we do provide references in which the antibodies were used for functional assays and we do perform QC to verify the specificity and quality of the antibody based on our strict specification criteria.
- Does BioLegend test each Ultra-LEAF™ antibody for potential pathogens?
-
No, BioLegend does not test for pathogens in-house unless otherwise indicated. However, we can recommend an outside vendor to perform this testing as needed.
- Have you tested this Ultra-LEAF™ antibody for in vivo or in vitro applications?
-
We don't test our antibodies for in vivo or in vitro applications unless otherwise indicated. Depending on the product, the TDS may describe literature supporting usage of a particular product for bioassay. It may be best to further consult the literature to find clone specific information.
Other Formats
View All CD307c/FcRL3 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
PE anti-human CD307c/FcRL3 | H5/FcRL3 | FC |
Ultra-LEAF™ Purified anti-human CD307c/FcRL3 | H5/FcRL3 | FC |
Alexa Fluor® 647 anti-human CD307c/FcRL3 | H5/FcRL3 | FC |
PE/Cyanine7 anti-human CD307c/FcRL3 | H5/FcRL3 | FC |
TotalSeq™-C0826 anti-human CD307c/FcRL3 | H5/FcRL3 | PG |
TotalSeq™-B0826 anti-human CD307c/FcRL3 Antibody | H5/FcRL3 | PG |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
PE anti-human CD307c/FcRL3
Human peripheral blood lymphocytes were surface stained with... Human peripheral blood lymphocytes were surface stained with... -
Ultra-LEAF™ Purified anti-human CD307c/FcRL3
Human peripheral blood lymphocytes were surface stained with... -
Alexa Fluor® 647 anti-human CD307c/FcRL3
Human peripheral blood lymphocytes were surface stained with... -
PE/Cyanine7 anti-human CD307c/FcRL3
Human peripheral blood lymphocytes were surface stained with... -
TotalSeq™-C0826 anti-human CD307c/FcRL3
-
TotalSeq™-B0826 anti-human CD307c/FcRL3 Antibody
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