FAK1 Pathway

Focal adhesion kinase 1 (FAK-1; also known as PTK2 protein tyrosine kinase 2) is important in cell migration, as its signaling pathways are key to the formation of focal adhesions that aid in the adhering of cells to the extracellular matrix. In apoptosis, the binding of FAK1 to RIPK1 and PI3K can induce survival signals, but the cleavage of FAK1 by Caspase 3 (or Calpain) is associated with death signaling and membrane formation during blebbing. FAK1 has also been shown to have roles in cell cycle progression and embryonic development.

 

Click on the poster below to view the interactive version.