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Integrins: Cell Mooring and Wayfaring
Integrins are transmembrane heterodimer proteins, consisting of an alpha (α) and beta (β) chain. Integrins are mainly known for mediating cell and extracellular matrix adhesion and migration. As such, integrins can play a pervasive role in cancer and tumor metastasis. They are integral in cell growth, division, differentiation, and apoptosis. But, they also play a role in broader biological events, like wound healing and apoptosis.

Use BioLegend’s Integrin Explorer to learn more about integrin interactions, function, structure, ligands, and available antibody products.
 
Show Explorer Show Chart Show Pathways
 
 
Alpha (α)
Beta (β)
Combinations
Instructions:
• Select an integrin from either the alpha or beta list.
• The possible combinations will populate in the middle and the available matches in the opposite column will remain blue.
• Select either a combination or blue item from the opposite column to display details.
• Click on a black colored item in the opposite column to switch.
 
1
2
3
4
5
6
7
8
9
10
11
D
E
IIb
L
M
V
X
1
2
3
4
5
6
7
8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Integrins β1 β2 β3 β4 β5 β6 β7 β8
α1 α1β1; VLA1; Laminin and Collagen Receptor N/A N/A N/A N/A N/A N/A N/A
α2 α2β1; VLA2; Collagen Receptor N/A N/A N/A N/A N/A N/A N/A
α3 α3β1; VLA3 N/A N/A N/A N/A N/A N/A N/A
α4 α4β1; VLA4; VCAM1 Receptor N/A N/A N/A N/A N/A α4β7; LPAM-1 N/A
α5 α5β1; VLA5; Fibronectin Receptor N/A α5β3 N/A α5β5 α5β6 N/A N/A
α6 α6β1; VLA6; Laminin Receptor N/A N/A α6β4 N/A N/A N/A N/A
α7 α7β1 N/A N/A N/A N/A N/A N/A N/A
α8 α8β1 N/A N/A N/A N/A N/A N/A N/A
α9 α9β1 N/A N/A N/A N/A N/A N/A N/A
α10 α10β1 N/A N/A N/A N/A N/A N/A N/A
α11 α11β1 N/A N/A N/A N/A N/A N/A N/A
αD N/A αDβ2 N/A N/A N/A N/A N/A N/A
αE N/A N/A N/A N/A N/A N/A αEβ7 N/A
αIIb N/A N/A αIIbβ3; GPIIbIIIa; CD41/CD61; Fibrinogen Receptor N/A N/A N/A N/A N/A
αL N/A αLβ2; LFA1; CD11a/CD18; ICAM1 Receptor; ICAM2 Receptor; ICAM3 Receptor N/A N/A N/A N/A N/A N/A
αM N/A αMβ2; CD11b/CD18; Mac1; CR3 (iC3b Receptor 3) N/A N/A N/A N/A N/A N/A
αV αVβ1 N/A αVβ3; CD51/CD61; VNR (Vitronectin Receptor) N/A αVβ5; αVβS; αVβ3B αVβ6 N/A αVβ8
αX N/A αXβ2; CD11c/CD18; P150,95; CR4 (iC3b Receptor 4) N/A N/A N/A N/A N/A N/A
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