Type I cytokine receptors are transmembrane receptors that recognize cytokines with four α-helical strands. The receptors of this family share a common amino acid motif (WSXWS) in the extracellular portion of the cell membrane. This family can be further subdivided based on whether the receptor complex utilizes the gp130, common beta chain (IL-2Rβ), or common gamma chain (IL-2Rγ) subunits. The functions of these family members are diverse, playing a major role in the development and function of immune and blood cells.

IL-2	IL-3	IL-4	IL-5	IL-6	IL-7	IL-9
IL-11 IL-12 IL-13 Set 1 IL-13 Set 2 IL-15 IL-16
IL-21	IL-23	IL-27	IL-31	IL-32	IL-34	IL-35