- Clone
- W18347A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Integrin αM chain, C3biR, CR3, Mac-1, Mo1, ITGAM
- Isotype
- Rat IgG2a, κ
-
Human peripheral blood mononuclear cells were stained with anti-human CD14 (clone HCD14) Brilliant Violet 421™ and anti-human CD11b (clone W18347A) APC (left) or rat IgG2a, κ APC isotype control (right). Data shown was gated on monocytes.
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 340007 | 25 tests | $95.00 | |||
| 340008 | 100 tests | $310.00 | |||
CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X.
Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Human CD11b recombinant protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Red Laser (633 nm)
- RRID
-
AB_3662236 (BioLegend Cat. No. 340007)
AB_3662236 (BioLegend Cat. No. 340008)
Antigen Details
- Structure
- Integrin, type I transmembrane glycoprotein, associates with integrin β2 (CD18), 165-170 kD
- Distribution
-
Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subset of T cells, subset of B cells
- Function
- Adhesion, phagocytosis, chemotaxis, neutrophil activation
- Interaction
- B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
- Ligand/Receptor
- ICAM-1(CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, factor X
- Cell Type
- B cells, Dendritic cells, Granulocytes, Monocytes, Neutrophils, NK cells, T cells, Tregs
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Innate Immunity
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Stewart M, et al. 1995. Curr. Opin. Cell Biol. 7:690.
- Gene ID
- 3684 View all products for this Gene ID
- UniProt
- View information about CD11b on UniProt.org
Other Formats
View All CD11b Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD11b Antibody | W18347A | FC |
| APC/Fire™ 750 anti-human CD11b | W18347A | FC |
| PE anti-human CD11b | W18347A | FC |
| PE/Cyanine7 anti-human CD11b | W18347A | FC |
| APC anti-human CD11b | W18347A | FC |
| PerCP/Cyanine5.5 anti-human CD11b | W18347A | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD11b Antibody
Human peripheral blood granulocytes were stained with purifi... -
APC/Fire™ 750 anti-human CD11b
Human peripheral blood granulocytes were stained with anti-h... -
PE anti-human CD11b
Human peripheral blood granulocytes were stained with anti-h... -
PE/Cyanine7 anti-human CD11b
Human peripheral blood monocytes were stained with anti-huma... -
APC anti-human CD11b
Human peripheral blood mononuclear cells were stained with a... -
PerCP/Cyanine5.5 anti-human CD11b
Human peripheral blood mononuclear cells were stained with a...