APC anti-human CD124 (IL-4Rα) Antibody

Pricing & Availability
Clone
G077F6 (See other available formats)
Regulatory Status
RUO
Other Names
IL-4 receptor α subunit
Isotype
Mouse IgG2a, κ
G077F6_APC_CD124_Antibody_FC_082913
Human peripheral blood lymphocytes were stained with CD19 FITC and CD124 (clone G077F6) APC (filled histogram) or mouse IgG2a, κ isotype control APC (dashed histogram). The data was analyzed by gating on CD19-positive cells.
  • G077F6_APC_CD124_Antibody_FC_082913
    Human peripheral blood lymphocytes were stained with CD19 FITC and CD124 (clone G077F6) APC (filled histogram) or mouse IgG2a, κ isotype control APC (dashed histogram). The data was analyzed by gating on CD19-positive cells.
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355005 25 tests $154.00
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355006 100 tests $350.00
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Description

CD124, also known as the alpha subunit of IL-4R, is a 140 kD transmembrane glycoprotein. It associates with either the common γ-chain (CD132) to form the type I IL-4R complex, which specifically binds IL-4, or with IL-13Ra1 to form the type II IL-4R heterodimeric complex, which binds and transduces signals from either IL-4 or IL-13.  A truncated form of IL-4Rα exists in the soluble form in biological fluids. CD124 is expressed on human B and T cells as well as a variety of other hematopoietic and non-hematopoietic cells and cell lines.  In B cells, CD124 can bind with IL-4 and IL-13 to regulate IgE antibody production. In T cells, the type I IL-4R (IL-4R/gC) is mostly responsible for Th2 cell expansion by mediating IL-4-dependent activation of the transcription factors in hematopoietic cells. The type II IL-4R (IL-4R/IL-13Ra1) is the main route for non-hematopoietic cell responses to IL-4 or IL-13.

Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human IL-4Rα Fc chimera
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Product Citations
  1. Miek L, et al. 2022. Immunology. 166:47. PubMed
  2. Yan YN, et al. 2023. Mediators Inflamm. 2023:8215567. PubMed
  3. Lee J, et al. 2017. PLoS One.. 10.1371/journal.pone.0183594. PubMed
  4. Bi CS, et al. 2020. Cell Prolif. 53:e12827. PubMed
  5. Grabosch S, et al. 2017. Gynecologic Oncology. 10.1016/j.ygyno.2017.04.008. PubMed
RRID
AB_2562507 (BioLegend Cat. No. 355005)
AB_2562507 (BioLegend Cat. No. 355006)

Antigen Details

Structure
140 kD type I transmembrane glycoprotein, associates with common γ chain or IL-13 receptor alpha-1 subunit
Distribution

B cells, T cells, endothelial cells, cancer cells

Function
Regulates IgE antibody production in B cells, Th2 cell expansion, and IL-4 or IL-13 induced response in non-hematopoietic cells
Interaction
STAT6
Ligand/Receptor
IL-4, IL-13
Cell Type
B cells, Endothelial cells, T cells
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Signal Transduction, Transcription Factors
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References
  1. Kashiwada M, et al. 2001. J. Immunol. 167:6382.
  2. Gilmour J, et al. 2008. Immunology 124:437.
  3. Hage T, et al. 1999. Cell 97:271.
Gene ID
3566 View all products for this Gene ID
UniProt
View information about CD124 on UniProt.org
Go To Top Version: 1    Revision Date: 09/06/2013

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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