APC anti-mouse CD127 (IL-7Rα) Antibody

Pricing & Availability
Clone
S18006K (See other available formats)
Regulatory Status
RUO
Other Names
IL-7 receptor α chain, IL-7Rα
Isotype
Rat IgG2b, λ
S18006K_APC_CD127_Antibody_042621
C57BL/6 mouse splenocytes were stained with anti-mouse CD3 FITC and anti-mouse CD127 (IL-7rα) (clone S18006K) APC (left) or rat IgG2b, κ APC isotype control (right).
  • S18006K_APC_CD127_Antibody_042621
    C57BL/6 mouse splenocytes were stained with anti-mouse CD3 FITC and anti-mouse CD127 (IL-7rα) (clone S18006K) APC (left) or rat IgG2b, κ APC isotype control (right).
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Cat # Size Price Quantity Check Availability
158205 25 µg $102.00
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158206 100 µg $311.00
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Description

CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development.

Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse IL7R-transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2892326 (BioLegend Cat. No. 158205)
AB_2892326 (BioLegend Cat. No. 158206)

Antigen Details

Structure
Type I transmembrane glycoprotein, associate with CD132, 60-90 kD
Distribution

Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells

Function
T cell and immature B cell proliferation and development
Ligand/Receptor
IL-7
Cell Type
B cells, T cells, Thymocytes
Biology Area
Immunology, Signal Transduction
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References
  1. Sudo T, et al. 1993. Proc Natl Acad Sci USA. 90:9125.
  2. Okuno Y, et al. 2002. Proc Natl Acad Sci USA. 99:6246.
  3. Pillai M, et al. 2004. Leuk Lymphoma. 45:2403.
Gene ID
16197 View all products for this Gene ID
UniProt
View information about CD127 on UniProt.org
Go To Top Version: 1    Revision Date: 04/26/2021

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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