APC anti-mouse/human CD44 Recombinant Antibody

Pricing & Availability
Clone
QA19A43 (See other available formats)
Regulatory Status
RUO
Other Names
Hermes, Pgp1, H-CAM, or HUTCH
Isotype
Rat IgG2a, κ
QA19A43_APC_CD44_RECOM_Antibody_090121.png
C57BL/6 splenocytes were stained with anti-mouse/human CD44 recombinant (clone QA19A43) APC (filled histogram) or rat IgG2a, κ APC isotype control (open histogram).
  • QA19A43_APC_CD44_RECOM_Antibody_090121.png
    C57BL/6 splenocytes were stained with anti-mouse/human CD44 recombinant (clone QA19A43) APC (filled histogram) or rat IgG2a, κ APC isotype control (open histogram).
Compare all formats See APC spectral data
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163603 25 µg $149.00
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163604 100 µg $350.00
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Description

CD44 is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. It has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

Technical data sheet

Product Details

Verified Reactivity
Mouse, Human
Antibody Type
Recombinant
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2894633 (BioLegend Cat. No. 163603)
AB_2894633 (BioLegend Cat. No. 163604)

Antigen Details

Structure
Variable splicing of CD44 gene generates many CD44 isoforms, 80-95 kD
Distribution

All leukocytes, epithelial cells, endothelial cells, hepatocytes, mesenchymal cells.

Function
Leukocyte attachment and rolling on endothelial cells, stromal cells and ECM.
Ligand/Receptor
Hyaluronan, MIP-1β, fibronectin, collagen.
Antigen References
  1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
  2. Haynes BF, et al. 1991. Cancer Cells. 3:347.
  3. Goldstein LA, et al. 1989. Cell. 56:1063.
  4. Mikecz K, et al. 1995. Nat Med. 1:558.
  5. Hegde V, et al. 2008. J Leukocyte Biol. 84:134.
  6. Liu T, et al. 2009. Biol Direct. 4:40.
Gene ID
12505 View all products for this Gene ID
UniProt
View information about CD44 on UniProt.org
Go To Top Version: 1    Revision Date: 09/01/2021

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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