- Clone
- QA18A18 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TCR-β chain, TCR-β, β-TCR
- Isotype
- Rat IgG1, κ
-
C57BL/6 mouse splenocytes were stained with anti-mouse TCR β chain recombinant (clone QA18A18) APC (left), or rat IgG1 κ APC isotype control (right). Cells were co-stained with CD3 PE.
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 159707 | 25 µg | $83.00 | |||
| 159708 | 100 µg | $213.00 | |||
T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR-β is a member of the immunoglobulin superfamily and a component of the CD3/TCR complex (along with TCR-α). It is expressed on α/β TCR-bearing T cells and thymocytes. The CD3/TCR complex plays a key role in antigen recognition, signal transduction, and T cell activation.
Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Recombinant
- Host Species
- Rat
- Immunogen
- Affinity purified TCR from mouse DO-11.10 cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Red Laser (633 nm)
- Application Notes
-
Clone QA18A18 of antibody can block binding of H57-597 clone on target and vice versa. The QA18A18 antibody can be used for T-cell activation. The QA18A18 antibody does not cross-react with γ/δ TCR-bearing T cells.
- RRID
-
AB_2888831 (BioLegend Cat. No. 159707)
AB_2888831 (BioLegend Cat. No. 159708)
Antigen Details
- Structure
- Ig superfamily
- Distribution
-
Majority of T cells and thymocytes (correlated to differentiation)
- Function
- Antigen recognition, T cell activation
- Interaction
- TCR α chain, CD3 complex
- Ligand/Receptor
- Peptide bound-MHC class I and II
- Cell Type
- T cells
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- TCRs
- Antigen References
-
1. Davis MM, et al. 1998. Ann. Rev. Immunol. 16:523.
2. Huppa JB, et al. 2003. Nat. Immunol. 4:749.
3. Kubo R, et al. 1989. J. Immunol. 142:2736. - Gene ID
- 21577 View all products for this Gene ID
- UniProt
- View information about TCR beta chain on UniProt.org
Other Formats
View All TCR β chain Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse TCR β chain Recombinant Antibody | QA18A18 | FC |
| PE anti-mouse TCR β chain Recombinant Antibody | QA18A18 | FC |
| FITC anti-mouse TCR β chain Recombinant Antibody | QA18A18 | FC |
| APC anti-mouse TCR β chain Recombinant Antibody | QA18A18 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse TCR β chain Recombinant Antibody
C57BL/6 splenocytes were stained with purified anti-mouse TC... -
PE anti-mouse TCR β chain Recombinant Antibody
C57BL/6 splenocytes were stained with anti-mouse TCR β chain... -
FITC anti-mouse TCR β chain Recombinant Antibody
C57BL/6 splenocytes were stained with anti-mouse TCR β chain... -
APC anti-mouse TCR β chain Recombinant Antibody
C57BL/6 mouse splenocytes were stained with anti-mouse TCR β...