- Clone
- RR4-7 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- T cell receptor beta 6
- Isotype
- Rat IgG2b, λ
-
C57BL/6 mouse splenocytes were stained with CD3 Brilliant Violet 421™ and APC TCR Vβ6 (clone RR4-7).
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 140005 | 25 µg | $113.00 | |||
| 140006 | 100 µg | $261.00 | |||
Vβ6 T cell receptor (TCR Vβ6) is a variant of TCR β chain and, along with TCR α chain, forms the TCR heterodimer. In association with the CD3 complex, TCR α/β is responsible for antigen recognition in the MHC-Peptide complex and the initiation of the T cell-mediated immune responses. Murine Vβ6 cells recognize the Mtv-7, Mls-1, and rabies superantigens.
Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- H-Y specific TH Clone OI11
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Red Laser (633 nm)
- Application Notes
-
Additional reported applications (for the relevant formats) include: induction of T cell proliferation1, blocking in vitro cytolysis1, and in vivo blocking of syngeneic T cell tumor growth2.
-
Application References
(PubMed link indicates BioLegend citation) -
- Kanagawa O and Palmer EBJ. 1989. Cell. Immunol. 119:412. (Activ, Block)
- Kanagawa O. 1989. J. Exp. Med. 170:1513. (Block)
- Product Citations
-
- RRID
-
AB_2564056 (BioLegend Cat. No. 140005)
AB_2564056 (BioLegend Cat. No. 140006)
Antigen Details
- Structure
- Member of the immunoglobulin superfamily, Vβ6 is a variant of the TCR β chain which associates with the TCR α chain to form the TCR heterodimer.
- Distribution
-
Expressed on a subset of TCR αβ+ T cells.
- Function
- Recognition of peptides presented in the MHC molecules, responsible for T cell mediated immune responses.
- Ligand/Receptor
- MHC-Peptide complex
- Cell Type
- T cells
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- TCRs
- Antigen References
-
1. Acha-Orbea H and MacDonald HR. 1995. Annu. Rev. Immunol. 13:459.
2. Rudy CK, et al. 1992. J. Exp. Med. 175:1613.
3. Jones LA, et al. 1990. Science 250:1726. - Gene ID
- 21577 View all products for this Gene ID
- UniProt
- View information about TCR Vbeta6 on UniProt.org
Other Formats
View All TCR Vβ6 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-mouse TCR Vβ6 | RR4-7 | FC |
| APC anti-mouse TCR Vβ6 | RR4-7 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
PE anti-mouse TCR Vβ6
C57BL/6 splenocytes stained with RR4-7 PE and CD3 APC -
APC anti-mouse TCR Vβ6
C57BL/6 mouse splenocytes were stained with CD3 Brilliant Vi...