Biotin anti-mouse CD155 (PVR) Antibody

Pricing & Availability
Clone
TX56 (See other available formats)
Regulatory Status
RUO
Other Names
PVR (poliovirus receptor) homolog
Isotype
Rat IgG2a, κ
TX56_Biotin_CD155_Antibody_102616
C57BL/6 mouse thymocytes were stained with biotinylated CD155 (clone TX56, filled histogram) or rat IgG2a, κ (open histogram), followed by streptavidin PE.
  • TX56_Biotin_CD155_Antibody_102616
    C57BL/6 mouse thymocytes were stained with biotinylated CD155 (clone TX56, filled histogram) or rat IgG2a, κ (open histogram), followed by streptavidin PE.
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131504 100 µg $253.00
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Description

Mouse CD155, also known as homolog of polivirus receptor (PVR), is the founding member of a subfamily of immunoglobulin-like adhesion receptors (nectins). Mouse CD155 is expressed on a wide variety of cells of hematopoietic origin apart from its existence on the epithelial cells. The engagement of CD155 with CD226 and CD96 induces cytotoxicity of NK cells and CTL.

Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
CD155 transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Tahara-Hanaoka S, et al. 2004. Int. Immunol. 16:533.
  2. Maier MK, et al. 2007. Eur. J. Immunol.. 37:2214.
  3. Bottino C, et al. 2003. J. Exp. Med. 198:557.
  4. Dressel R, et al. 2010. FASEB J. 9:134. PubMed
RRID
AB_2632604 (BioLegend Cat. No. 131504)

Antigen Details

Structure
70 kd immunoglobulin-like molecule with three Ig-like domains.
Distribution

CD155 is expressed at cell junctions on the primary vascular endothelial cells. Moreover, mouse CD155 is highly expressed on DP thymocytes and expression level is dropped in peripheral single positive CD4+ and CD8+ T cells. CD155 can be detected on T reg, other activated T cells and on NKT cells. Resident monocytes express moderate amount of CD155, but upregulated its expression during inflammation. Other cells, such as IEL, neutrophils and subsets of B cells were found to express CD155 to varying extents.

Function
Apart from its function of adhering junction among contacting epithelial cells, the interaction of DNAM-1 (CD226) with its ligands CD155 and CD112 (nectin 2) induces cytotoxcity of NK cells and CD8+ T cells and cytokine secretion.
Ligand/Receptor
CD226 (DNAM-1), CD96
Cell Type
B cells, Endothelial cells, Neutrophils, Thymocytes, Tregs
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules, Immune Checkpoint Receptors
Antigen References

1. Mendelsohn C, et al. 1989. Cell 56:855.

Gene ID
52118 View all products for this Gene ID
UniProt
View information about CD155 on UniProt.org
Go To Top Version: 1    Revision Date: 10/27/2016

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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