- Clone
- QA17A35 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Macrophage mannose receptor, Mannose receptor, MCR1
- Isotype
- Rat IgG1, κ
-
Thioglycollate-elicited BALB/c mouse peritoneal macrophages were surface stained with anti-mouse/human CD11b (clone M1/70) APC. Cells were then fixed, permeabilized, and intracellularly stained with anti-mouse CD206 (MMR) recombinant (clone QA17A35) FITC (left) or rat IgG1, κ FITC isotype control (right).
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 162507 | 25 µg | $180.00 | |||
| 162508 | 100 µg | $400.00 | |||
CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.
Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Recombinant
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
- Application Notes
-
This recombinant antibody clone is derived from clone C068C2.
- RRID
-
AB_3097515 (BioLegend Cat. No. 162507)
AB_3097515 (BioLegend Cat. No. 162508)
Antigen Details
- Structure
- Type I transmembrane protein, 175 kD, C-type lectin superfamily
- Distribution
-
Macrophages, dendritic cells, Langerhans cells, liver endothelial cells
- Function
- Pathogen recognition, endocytosis and phagocytosis, antigen presentation
- Ligand/Receptor
- Antigen containing mannose, fucose, or an N-acetyl glucosamine
- Antigen References
-
1. Wileman TE, et al. 1986. P. Natl. Acad. Sci. USA 83:2501.
2. Apostolopoulos V, et al. 2001. Curr. Mol. Med. 1:469.
3. Kitamura T. et al. 2018. Front Immunol. 8:2004
4. Laoui D. et al. 2011. Int. J. Dev. Biol. 55: 861 - 867 - Gene ID
- 17533 View all products for this Gene ID
- UniProt
- View information about CD206 on UniProt.org
Other Formats
View All CD206 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse CD206 (MMR) Recombinant Antibody | QA17A35 | ICFC |
| PE anti-mouse CD206 (MMR) Recombinant Antibody | QA17A35 | ICFC |
| APC anti-mouse CD206 (MMR) Recombinant Antibody | QA17A35 | ICFC |
| FITC anti-mouse CD206 (MMR) Recombinant Antibody | QA17A35 | ICFC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse CD206 (MMR) Recombinant Antibody
Thioglycollate-elicited BALB/c mouse peritoneal macrophages ... -
PE anti-mouse CD206 (MMR) Recombinant Antibody
Thioglycollate-elicited BALB/c mouse peritoneal macrophages ... -
APC anti-mouse CD206 (MMR) Recombinant Antibody
Thioglycollate-elicited BALB/c mouse peritoneal macrophages ... -
FITC anti-mouse CD206 (MMR) Recombinant Antibody
Thioglycollate-elicited BALB/c mouse peritoneal macrophages ...