- Regulatory Status
- RUO
- Other Names
- MCP2, Chemokine (C-C motif) ligand 8, small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 442204 | 5 plates | $347.00 | |||
Please contact our sales representative for bulk pricing quotations.
Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP-2), is a protein which in humans is encoded by the CCL8 gene. CCL8 belongs to the CC chemokine family and is up-regulated in inflammed tissues. It binds to several G proteincoupled receptors including CCR1, CCR2, CCR3 and CCR5. It activates and attracts many different immune cells. High levels of CCL8 are associated with tuberculosis (TB) and graft-versus-host disease (GVHD) following hematopoietic stem-cell transplantation (HSCT). Since it recognizes the receptor CCR5, which is a major co-receptor for HIV-1, CCL8 has been investigated for its potential as an inhibitor for HIV infection.
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Kit Contents
- Kit Contents
-
- Human CCL8 ELISA MAX™ Capture Antibody (200X)
- Human CCL8 ELISA MAX™ Detection Antibody (200X)
- Human CCL8 Standard
- Avidin-HRP (1000X)
- Substrate Solution D
- Coating Buffer A (5X)
- Assay Diluent A (5X)
- Assay Buffer D
Product Details
- Verified Reactivity
- Human
- Application
-
ELISA
- As a part of BioLegend's efforts to go green, each new lot of the ELISA MAX™ sets will include a summarized version of its manual. Click here for more information.
- Product Citations
-
- Sensitivity
- 4.0 pg/mL
- Standard Range
- 7.8 - 500 pg/mL
- Materials Not Included
-
- Microwell plates: 96-well Nunc MaxiSorp™ is recommended.
- A microplate reader capable of of measuring absorbance at 450 nm
- Adjustable pipettes to measure volumes ranging from 2 µL to 1 mL
- Deionized (DI) water
- PBS (Phosphate-Buffered Soaline): 8.0 g NaCl, 1.16 g Na2HPO4, 0.2 g KH2PO4, 0.2 g KCL, add deionized water to 1 L; pH to 7.4, 0.2 µm filtered.
- Wash Buffer: Phosphate-Buffered Saline (PBS) + 0.05% Tween-20. BioLegend Cat. No. 421601 is recommended.
- Wash bottle or automated microplate washer
- Stop Solution (acid solution e.g. 2N H2SO4) BioLegend Cat. No. 423001
- Log-Log graph paper or software for data analysis
- Tubes to prepare standard dilutions
- Timer
- Plate Sealer
- Absorbent Paper
Antigen Details
- Biology Area
- Cell Biology, Neuroinflammation, Neuroscience
- Molecular Family
- Cytokines/Chemokines
- Gene ID
- 6355 View all products for this Gene ID
- UniProt
- View information about CCL8 on UniProt.org