PE anti-human CD85g (ILT7) Antibody

Pricing & Availability
Clone
17G10.2 (See other available formats)
Regulatory Status
RUO
Other Names
CD85g, immunoglobulin-like transcript 7, LILRA4
Isotype
Mouse IgG1, κ
17G10_PE_070207
CD14- human peripheral blood mononuclear cells stained with CD123 APC and 17G10.2 PE
  • 17G10_PE_070207
    CD14- human peripheral blood mononuclear cells stained with CD123 APC and 17G10.2 PE
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Cat # Size Price Quantity Check Availability
326408 100 tests $317.00
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Description

ILT7 (immunoglobulin-like transcript 7) is a member of leukocyte immunoglobulin-like receptor (LIR or LILR) gene family, also known as CD85g and LILRA4. It contains four extracellular Ig domains. In association with FcεR1γ, ILT7 forms a receptor complex that transduces ITAM-mediated signals. ILT7 is specifically expressed on plasmacytoid dendritic cells (pDCs), but not on myeloid dendritic cells and other peripheral blood leukocytes. ILT7 negatively regulates the innate immune functions of human pDCs. Cross-linking 17G10.2 antibody is able to trigger ILT7 mediated signaling.

Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported (for the relevant formats) applications include: trigger ILT7 mediated signaling.The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 326413 and 326414).

Application References

(PubMed link indicates BioLegend citation)
  1. Jensen MA, et al. 2013. Ann Rheum Dis. 72:596. PubMed.
Product Citations
  1. Jensen M, et al. 2013. Ann Rheum Dis. 72:596. PubMed
  2. Bego M, et al. 2015. J Vis Exp. 103: 51207. PubMed
  3. Pham TNQ, et al. 2020. Cell Reports. 29(9):2770-2782.e5.. PubMed
  4. Bego M, et al. 2015. PLoS Pathog. 11: 1005024. PubMed
RRID
AB_2136375 (BioLegend Cat. No. 326408)

Antigen Details

Structure
Associate with FcεR1γ leukocyte immunoglobulin-like receptor gene family
Distribution

Plasmacytoid dendritic cells

Function
Negatively regulates pDC mediated innate immune function
Cell Type
Dendritic cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References

1. Cao W, et al. 2006. J. Exp. Med. 203(6):1399.
2. Brown D, et al. 2004. Tissue Antigen. 64:215.
3. Rissoan MC, et al. 2002. Blood 100:3295.

Gene ID
23547 View all products for this Gene ID
UniProt
View information about CD85g on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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