- Clone
- H132 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- T cell receptor Vβ13.2 chain
- Isotype
- Mouse IgG1, κ
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Human peripheral blood lymphocytes stained with CD3 (UCHT1) APC and H132 PE
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 333108 | 100 tests | $268.00 | |||
The Vβ13.2 TCR is a variant of the TCR β chain. It belongs to Ig superfamily and is expressed by a subset of peripheral blood T cells and some T cell clones. Vβ expression in humans and mice has been used to study the effects of superantigens and also to examine the repertoires of T cells involved in inflammatory and autoimmune disease. It is reported that Vβ13.2 TCRs possess very unusually long β-chain CDR3 regions and are expressed on CTL specific for the immunodominant human HLA-B8–restricted HIV-1 nef epitope, FLKEKGGL (FL8). CTL expressing V β13.2 TCRs tolerate naturally arising viral variants in the FL8 epitope that escape recognition by other CTL. The clone H132 recognizes the Vβ13.2 allele product but does not react with the Vβ13.1, 13.3, 13.5 and 13.6 allele products of the Vβ13 subfamily.
Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human TCR Vβ13.2 transfectant
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
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Application References
(PubMed link indicates BioLegend citation) -
- Choi Y, et al. 1991. Proc. Natl. Acad. Sci. USA 88:8357.
- Product Citations
-
- RRID
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AB_1027668 (BioLegend Cat. No. 333108)
Antigen Details
- Structure
- Immunoglobulin superfamily
- Distribution
-
T cells, thymocytes
- Function
- Antigen recognition, activation of TCR Vβ13.2 bearing T cells
- Ligand/Receptor
- Peptide bound to MHC
- Cell Type
- T cells, Thymocytes
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- TCRs
- Antigen References
-
1. Choi Y, et al. 1991. Proc. Natl. Acad. Sci. USA 88:8357.
2. Dong T, et al. 2004. J. Exp. Med. 200:1547. - Gene ID
- 6957 View all products for this Gene ID
- UniProt
- View information about TCR Vbeta13.2 on UniProt.org
Other Formats
View All TCR Vβ13.2 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-human TCR Vβ13.2 | H132 | FC |
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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PE anti-human TCR Vβ13.2
Human peripheral blood lymphocytes stained with CD3 (UCHT1) ...