- Clone
- RR3-15 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TCR Vβ-11, V beta 11 TCR, Vβ11 T-cell receptor
- Isotype
- Rat IgG2b, κ
-
C57BL/6 mouse splenocytes stained with CD3 (145-2C11) APC and RR3-15 PE -
C57BL/6 mouse splenocytes stained with CD3 (145-2C11) APC and rat IgG2b, κ (RTK4530) PE isotype control
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 139003 | 25 µg | $98.00 | |||
| 139004 | 100 µg | $214.00 | |||
T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR-β is a member of the immunoglobulin superfamily and a component of the CD3/TCR complex. The CD3/TCR complex plays a key role in antigen recognition, signal transduction, and T cell activation. V β 11-bearing T cells are largely absent from strains of mice that express MHC class II molecule I-E. It has been demonstrated that the expression of I-E molecule is necessary for the clonal deletion of V beta 11-bearing T cells, but not sufficient for the clonal elimination of V beta 11-bearing T cells.
Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse cytolytic T-cell clone OH6
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
-
Additional reported applications (for relevant formats) include: Western Blot1.
-
Application References
(PubMed link indicates BioLegend citation) -
- Bill J, et al. 1989. J. Exp. Med. 169:1405. (WB)
- Product Citations
-
- RRID
-
AB_10612759 (BioLegend Cat. No. 139003)
AB_10612759 (BioLegend Cat. No. 139004)
Antigen Details
- Structure
- A member of Ig superfamily, heterodimerized with α TCR α chain, and associated with CD3 complex.
- Distribution
-
Subsets of T cells and thymocytes.
- Function
- Antigen recognition.
- Ligand/Receptor
- Antigens
- Cell Type
- T cells, Thymocytes
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- TCRs
- Antigen References
-
1. Davis MM, et al. 1998. Ann. Rev. Immunol. 16:523.
2. Kubo R, et al. 1989. J. Immunol. 142:2736.
3. Haqqi TM, et al. 1989. J. Exp. Med. 169:1903.
4. Behlke MA, et al. 1986. Proc. Natl. Acad. Sci. USA 83:767.
5. Gao EK, et al. 1989. J. Exp. Med. 170:1947. - Gene ID
- 21577 View all products for this Gene ID
- UniProt
- View information about TCR Vbeta11 on UniProt.org
Other Formats
View All TCR Vβ11 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-mouse TCR Vβ11 | RR3-15 | FC |
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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