- Clone
- MR12-4 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Vβ13 T-cell receptor, T cell receptor beta 13
- Isotype
- Mouse IgG1, κ
-
BALB/c splenocytes stained with MR12-4 PE and CD3 APC
| Cat # | Size | Price | Quantity Check Availability | ||
|---|---|---|---|---|---|
| 140703 | 25 µg | $129.00 | |||
| 140704 | 100 µg | $268.00 | |||
Vβ13 T cell receptor (TCR Vβ13) is a variant of TCR β chain that along with TCR α chain forms the TCR heterodimer. In association with the CD3 complex, TCR α/β is responsible for antigen recognition in the MHC-Peptide complex and initiation of T cell-mediated immune responses. The most frequently β chains found in the immune response to myelin basic protein (MBP) in B10.PL mice are Vβ13 and Vβ8.2.
Product Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
-
Additional reported applications (for the relevant formats) include: in vitro blocking of antigen-induced proliferation of Vβ13+ T cells 1 and in vivo depletion of Vβ13+ T cells1.
-
Application References
(PubMed link indicates BioLegend citation) -
- Zaller DM, et al. 1990. J. Exp. Med. 171:1943. (Block)
- Product Citations
-
- RRID
-
AB_10639945 (BioLegend Cat. No. 140703)
AB_10639945 (BioLegend Cat. No. 140704)
Antigen Details
- Structure
- Member of the immunoglobulin superfamily, Vβ13 is a variant of the TCR β chain which associates with the TCR α chain to form the TCR heterodimer.
- Distribution
-
Expressed on a subset of TCR αβ+ T cells.
- Function
- Recognition of peptides presented by the MHC molecules, responsible for T cell mediated immune responses.
- Ligand/Receptor
- MHC-Peptide complex
- Cell Type
- T cells
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- TCRs
- Antigen References
-
1. Zaller DM, et al. 1990. J. Exp. Med. 171:1943.
2. Gentile F, et al. 2004. Immunology 112:13.
3. Lode HN, et al. 1999. P. Natl. Acad. Sci. USA 96:8591. - Gene ID
- 21577 View all products for this Gene ID
- UniProt
- View information about TCR Vbeta13 on UniProt.org
Other Formats
View All TCR Vβ13 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-mouse TCR Vβ13 | MR12-4 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
PE anti-mouse TCR Vβ13
BALB/c splenocytes stained with MR12-4 PE and CD3 APC