Purified anti-human CD11b Antibody

Pricing & Availability
Clone
LM2 (See other available formats)
Regulatory Status
RUO
Other Names
Integrin αM chain, C3biR, CR3, Mac-1, Mo1, ITGAM
Isotype
Mouse IgG1, κ
LM2_Pure_CD11b_Antibody_032218
Human peripheral blood lymphocytes, monocytes, and granulocytes were stained with purified CD11b (clone LM2) (left) or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE.
  • LM2_Pure_CD11b_Antibody_032218
    Human peripheral blood lymphocytes, monocytes, and granulocytes were stained with purified CD11b (clone LM2) (left) or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE.
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Cat # Size Price Quantity Check Availability
393102 100 µg $218.00
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Description

CD11b is a 165-170 kD type I transmembrane glycoprotein also known as αM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin β2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and factor X.

Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
β2 integrins from granulocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

LM2 does not block clone ICRF44 indicating a unique epitope.

Product Citations
  1. Halder LD, et al. 2020. Nat Commun. 2.077083333. PubMed
RRID
AB_2728424 (BioLegend Cat. No. 393102)

Antigen Details

Structure
Integrin, type I transmembrane glycoprotein, associates with integrin β2 (CD18), 165-170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subset of T cells, subset of B cells

Function
Adhesion, phagocytosis, chemotaxis, neutrophil activation
Ligand/Receptor
ICAM-1(CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, factor X
Cell Type
Granulocytes, Monocytes, Macrophages, Dendritic cells, NK cells, T cells, B cells, Neutrophils
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Costimulatory Molecules
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References
  1. Stewart M, et al. 1995. Curr Opin Cell Biol. 7:690.
  2. Miller LJ, et al. 1986. J Immunol. 137(9):2891.
Gene ID
3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org
Go To Top Version: 1    Revision Date: 03/23/2018

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